小鼠微核法测定胆碱的致裂活性

Brazilian Journal of Genetics Pub Date : 1997-09-01 DOI:10.1590/S0100-84551997000300008

M. C. Gimmler-Luz, B. Erdtmann

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引用次数: 3

摘要

采用两种浓度(18.75 mg/kg和37.5 mg/kg)和不同时间的急性给药方法，对巴西塞内西奥(Senecio brasiliensis)中吡罗里西啶类生物碱integerrimine进行了实验，以确定其在小鼠红细胞中诱导微核的能力。这种生物碱能够增加骨髓和外周血红细胞中微核多染红细胞的频率

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Clastogenic activity of integerrimine determined in mouse micronucleus assays

The pyrrolizidine alkaloid integerrimine, obtained from Senecio brasiliensis, was tested by acute dosing at two concentrations (18.75 and 37.5 mg/kg), and at different times, to establish its ability to induce micronuclei in mouse erythrocytes. This alkaloid was able to increase the frequency of micronucleated polychromatic erythrocytes in both, bone marrow and peripheral blood erythrocytes

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来源期刊

Brazilian Journal of Genetics

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