阿尔茨海默氏症的认知障碍可以通过降低血液同型半胱酸来治愈

T. Hasegawa, T. Uchida, A. Chanoki
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引用次数: 0

摘要

近年来淀粉样蛋白治疗阿尔茨海默病的两大临床试验均未能恢复认知功能障碍,这迫使我们重新考虑淀粉样蛋白致病菌是阿尔茨海默病的中心假说。我们最近发表了人类阿尔茨海默氏症患者显示出迷你精神状态检查(MMSE)评分与血液同型半胱酸(HA)水平之间的密切关系。但这一关系并未显示出HA的致病作用。因此我们研究了血HA对MMSE评分的致病作用,即血HA水平的变化是如何影响MMSE评分的?6例AD患者(均为女性,年龄分别为77、82、86、87、91、91),每餐服用绿茶粉1g,疗程2个月。分别测定服用绿茶粉前后血HA水平和MMSE评分。探讨血HA水平变化与MMSE评分变化的关系。血HA水平变化与MMSE评分变化呈显著负相关:r=-0.96, p=0.00018, n=6。从我们的观察来看,血液HA水平的改变引起MMSE评分的改变,即阿尔茨海默氏症的认知能力受血液HA水平的控制。现在我们可以展示一些健康的食物,被称为HBF,可以100%恢复阿尔茨海默氏症的认知障碍通过降低外周血中的同型半胱酸。我们进行了HBF对阿尔茨海默氏症和路易体痴呆患者认知恢复的公开试验。2名男性路易体痴呆患者,11名女性阿尔茨海默病患者入组。所有患者均为终末期。每餐补充1.5g HBF,持续1-2个月。分别在摄入HBF前后测量MMSE评分。采用酶联免疫吸附试验(ELISA)测定两组患者服药前后血同型半胱酸水平。结果非常令人震惊。100%的患者认知功能恢复。HBF降低了他们的血同型半胱酸水平。现在我们对阿尔茨海默病患者做了一个比较大的公开试验。91例患者入组。采用新临床精神状态评定量表(NM)对两组患者的认知恢复情况进行测量。所有服用HBF的患者均表现出行为的恢复。从HBF的公开试验中,可以证实许多事实。(1)阿尔茨海默氏症的认知障碍甚至在终末期都可以恢复。(2)同型半胱酸诱发阿尔茨海默病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ALZHEIMER’S COGNITIVE IMPAIRMENT CAN BE CURED BY DECREASING BLOOD HOMOCYSTEIC ACID
Recent big two clinical trials of amyloid beta treatment for Alzheimer’s disease are all failed to recover the cognitive impairment, it has forced us to reconsider the central hypothesis of amyloid pathogen for Alzheimer’s disease. We recently published that human Alzheimer’s patients showed the strong relationship between Mini Mental State Examination (MMSE) scores and blood homocysteic acid (HA) level. However this relationship did not show the pathogenic action of HA. So we investigated the pathogenic effect of blood HA on MMSE score, that is, how does blood HA level change affect MMSE score? 6 AD patients (all female: age 77, 82, 86,87, 91, 91) were given green tea powder 1g at every meal for 2 months. Their blood HA level and MMSE score were measured before and after taking green tea powder. The relationship between blood HA level change and MMSE score change was investigated. The strong statistically significant negative relationship between blood HA level change and MMSE score change: r=-0.96, p=0.00018, n=6. From our observation, it shows that blood HA level change induced MMSE score change, that is, Alzheimer’s cognitive ability was controlled by blood HA level. Now we can present that some healthy food, that is named HBF, can recovered 100% Alzheimer’s cognitive impairment by the decreasing the homocysteic acid in a peripheral blood. We made the open-trial of HBF on the Alzheimer’s and lewy bodies dementia’s cognitive recovery. Two male lewy bodies dementia patients, 11 female Alzheimer’s patients were enrolled. All patients were at end stage. They ingested HBF supplement 1.5g at every meals for 1-2 months. Their MMSE scores were measured before and after their HBF ingestion. Their blood homocysteic acid levels were measured by ELISA method before and after their ingestions. Results were extremely amaging. 100% of all patients showed their cognitive recovery. Their blood homocysteic acid decreased their level by HBF. Now we have made a relative large open trial of AD patients. 91 patients were enrolled. Their cognitive recovery were measured by NM scale (New Clinical Scale for Rating of Mental States). All patients who took HBF showed the recovery of their behaviors. From this open-trial of HBF, many facts can be confirmed. (1) Alzheimer’s cognitive impairment can be recovered at even end stage. (2) Alzheimer’s disease is induced by homocysteic acid.
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