PATHOMORPHOLOGICAL ASPECTS OF THE PERITONEAL CAVITY ADHESION PROCESS DEVELOPMENT I N ACUTE SURGICAL PATHOLOGY

Summary. The aim of the study. To study the pathomorphological changes in adhesion formation, and to determine the main critical moments of adhesiogenesis in adhesion disease due to acute inflammatory injuty to the peritoneum. Materials and methods. The study included 28 cases of adhesion formation in operated patients (average age — 27.91±4.61 yrs). The material was collected intraoperatively in accordance with standard requirements for the production of histological preparations. To obtain differentiated polychromy of tissues, staining of micropreparations with hematoxylin-eosin and the van Gieson method were used. Results and their discussion. The histological picture varied from immature granulation tissue to signs of degenerative changes in the tissue of the formed adhesions. In some cases, the development of the adhesion process acquired features of combined fibrous and fatty degeneration. The obtained data showed a clear phasic development of adhesiogenesis from the inflammatory process to the formation of powerful connective tissue structures with the phenomena of hyalinosis and secondary degenerative changes. Conclusions. The study of the patterns of formation of the adhesion process showed that adhesion disease is characterized by a certain phasic development of changes from alternative damage and non-specific inflammation to the formation of sufficiently differentiated connective tissue and changes of a secondary degenerative nature. The obtained data create prerequisites for the development of methods of influence (prevention) at each stage of the development of adhesion disease and adhesiogenesis.