Effect of Linseed Oil Supplementation on Lipid Peroxidation and Antioxidant Capacity in Pregnant Overfed Obese Rats and Their Offspring

The aim of the present study was to evaluate the protective effects of linseed oil on lipid peroxidation, antioxidative capacity, as well as serum glucose, total cholesterol (TC), LDL-C and TG levels, in cafeteria-diet-fed dams during gestation and lactation, and in their offspring throughout adulthood. Food and energy intakes were also evaluated. The cafeteria diet led to higher energy intake, body weight, hyperglycemia and hyperlipidemia (higher TC, LDL-C and TG) in dams’ rats and their pups. Plasma vitamin C, Erythrocyte GSH levels and catalase activity were lower, whereas plasma diene conjugates (DC), Malondialdehyde and protein carbonyl levels (PC) in plasma and erythrocytes were higher in cafeteria-diet-fed mothers and their pups compared to controls. Supplement of linseed oil significantly enhanced plasma antioxidant defense capacities, as evaluated by the marked increase in the levels of plasma vitamin C and erythrocyte GSH as well as the activities of CAT and the significant reduction in lipid peroxidation (lower DC and MDA) and PC in CAFL-diet-fed mothers and their offspring. Simultaneous intake of linseed oil also reduced body weight, plasma TG, TC and LDL-C contents in obese pregnant and lactating dams and their pups at day 30 and day 90. The flaxseed oil supplementation may prevent lipid peroxidation and metabolic disorders which might be helpful in preventing obesity complications in mothers during pregnancy and lactation and in their offspring. REFERENCES:Adeoye, O., Olawumi, J., Opeyemi, A., & Christiania, O. (2016). Review on the role ofglutathione on oxidative stress and infertility. JBRA Assisted Reproduction, 22(1), 61-66.Aebi, H. (1974). Catalase. 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