[一系列取代亚氨基二氢呋喃的电子结构和辐射防护活性]。

Radiobiologiia Pub Date : 1992-09-01

E E Khutorskaia, G S Beloglazov, E L Izmozherova, A N Filaretov, Iu M Skvortsov

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引用次数: 0

摘要

在亚氨基二氢呋喃系列中发现了提高暴露致死杂交(CBA x C57B1/6)F1小鼠存活率的化合物。用MNDO方法进行的量子化学估计表明，能够与DNA核苷酸发生供体-接受相互作用并具有与核苷酸电子结构相当的供体轨道能量的物质具有辐射防护作用。

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[The electronic structure and radiorprotective activity of a series of substituted iminodihydrofurans].

Compounds that increase the survival rate of lethally exposed hybrid (CBA x C57B1/6)F1 mice have been revealed within the series of iminodihydrofurans. The quantum-chemical estimates, made by the MNDO method, show that substances which are capable of donor-acceptance interaction with DNA nucleotides and have the energy of donor orbitals, comparable with the electron structure of nucleotides, possess radioprotective efficacy.

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Radiobiologiia

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