[确定药物对低剂量和亚致死剂量电离辐射防护性能的实验方法]。

Radiobiologiia Pub Date : 1992-09-01
K S Chertkov, V A Glushkov, M F Sbitneva, L A Vernigorova, V G Chotiĭ, T S Maliutina
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引用次数: 0

摘要

在小鼠实验中,通过9个参数估计了辐射防护剂对非致死和低剂量(0.5-4 Gy)急性γ辐照的有效性。在辐照前(< 2 Gy)给予半胱胺、半胱胺和核糖素处理,不影响所研究参数的辐照后值。当剂量高达4戈瑞时,观察到利博辛的作用。异常有丝分裂的数量,骨髓的细胞结构和有丝分裂活性的测定已被证明是最翔实的。对所获得的数据进行了讨论,并适当考虑了低水平辐射的具体影响和所研究的物质的保护作用机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[An experimental approach to determining the protective properties of drugs against ionizing radiation in low and sublethal doses].

In experiments with mice, the efficiency of radioprotective agents against acute gamma-irradiation with nonlethal and low doses (0.5-4 Gy) was estimated by nine parameters. The treatment with cystamine, cysteamine and riboxine prior to irradiation (< 2 Gy) did not influence the postirradiation values of the parameters under study. With a dose of up to 4 Gy, the effect of riboxine was noted. The determinations of the number of aberrant mitoses, cellularity and mitotic activity of the bone marrow have proved to be most informative. The data obtained are discussed with due regard for the specific effect of low-level radiation and mechanisms of the protective action of the agents under study.

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