Tareq El-Shamy, H. Mandour, M. Assadawy, O. Shaker
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Subjects and methods: The study was carried out using thirty-four patients of both sexes ranging in age between 30-50 years old with symptomatic erosive OLP and treated with intra-lesional 1% low molecular weight chitosan (50,000-190,000 Da) obtained from (Sigma-Aldrich, St. Louis, MO) and five healthy volunteers for estimation of the mean of normal salivary TNF-α. The appearance score, pain score, and salivary TNF-α of the target lesions were evaluated at weeks 0, 2, 4, and 16. Results: The study showed that there was a significant reduction of the mean of salivary TNF-α, VAS, score and criteria of clinical data which continued up to the end of the 4 months evaluation period as compared to the mean baseline value. Conclusion: Topical intra-lesional chitosan injection is effective for erosive OLP, which suggests that topical intra-lesional chitosan injection can be a promising therapeutic alternative for erosive OLP.","PeriodicalId":117944,"journal":{"name":"Al-Azhar Journal of Dental Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of chitosan as a treatment modality for erosive oral lichen planus via detection of salivary TNF-α\",\"authors\":\"Tareq El-Shamy, H. Mandour, M. Assadawy, O. Shaker\",\"doi\":\"10.21608/ajdsm.2021.68883.1191\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease in which T-cell mediated immune responses are implicated in the pathogenesis. TNF has been found to be involved in the pathogenesis of many inflammatory or autoimmune diseases such as lichen planus. Various treatments have been employed to treat symptomatic OLP, but a complete cure is very difficult to achieve because of its recalcitrant nature. Topical corticosteroids therapy of OLP has shown conflicting results in many reports. Natural products have served as a major source of drugs for centuries, this study aimed to evaluate the effectiveness of topical intra-lesional chitosan in the treatment of oral erosive lichen planus. This was achieved via detection of salivary TNF-α level. Subjects and methods: The study was carried out using thirty-four patients of both sexes ranging in age between 30-50 years old with symptomatic erosive OLP and treated with intra-lesional 1% low molecular weight chitosan (50,000-190,000 Da) obtained from (Sigma-Aldrich, St. Louis, MO) and five healthy volunteers for estimation of the mean of normal salivary TNF-α. The appearance score, pain score, and salivary TNF-α of the target lesions were evaluated at weeks 0, 2, 4, and 16. Results: The study showed that there was a significant reduction of the mean of salivary TNF-α, VAS, score and criteria of clinical data which continued up to the end of the 4 months evaluation period as compared to the mean baseline value. 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引用次数: 0
摘要
目的:口腔扁平苔藓(OLP)是一种常见的慢性炎症性粘膜疾病,其发病机制与t细胞介导的免疫应答有关。TNF已被发现参与许多炎症性或自身免疫性疾病的发病机制,如扁平苔藓。各种治疗方法已被用于治疗症状性OLP,但由于其顽固性,完全治愈是非常困难的。局部皮质类固醇治疗OLP在许多报告中显示出相互矛盾的结果。几个世纪以来,天然产物一直是药物的主要来源,本研究旨在评估局部病灶内壳聚糖治疗口腔糜烂性扁平苔藓的有效性。这是通过检测唾液TNF-α水平实现的。研究对象和方法:研究对象为34名男女,年龄在30-50岁之间,患有症状性糜糜性OLP,病变内使用来自(Sigma-Aldrich, St. Louis, MO)的1%低分子量甲酰糖(50,000-190,000 Da)治疗,以及5名健康志愿者,以估计正常唾液TNF-α的均值。分别于第0、2、4、16周评估目标病变的外观评分、疼痛评分和唾液TNF-α。结果:研究显示,与平均基线值相比,持续到4个月评估期结束时,唾液TNF-α、VAS、评分和临床数据标准的平均值均有显著降低。结论:局部病灶内注射壳聚糖治疗糜烂性OLP疗效显著,是治疗糜烂性OLP的理想选择。
Evaluation of chitosan as a treatment modality for erosive oral lichen planus via detection of salivary TNF-α
Objective: Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease in which T-cell mediated immune responses are implicated in the pathogenesis. TNF has been found to be involved in the pathogenesis of many inflammatory or autoimmune diseases such as lichen planus. Various treatments have been employed to treat symptomatic OLP, but a complete cure is very difficult to achieve because of its recalcitrant nature. Topical corticosteroids therapy of OLP has shown conflicting results in many reports. Natural products have served as a major source of drugs for centuries, this study aimed to evaluate the effectiveness of topical intra-lesional chitosan in the treatment of oral erosive lichen planus. This was achieved via detection of salivary TNF-α level. Subjects and methods: The study was carried out using thirty-four patients of both sexes ranging in age between 30-50 years old with symptomatic erosive OLP and treated with intra-lesional 1% low molecular weight chitosan (50,000-190,000 Da) obtained from (Sigma-Aldrich, St. Louis, MO) and five healthy volunteers for estimation of the mean of normal salivary TNF-α. The appearance score, pain score, and salivary TNF-α of the target lesions were evaluated at weeks 0, 2, 4, and 16. Results: The study showed that there was a significant reduction of the mean of salivary TNF-α, VAS, score and criteria of clinical data which continued up to the end of the 4 months evaluation period as compared to the mean baseline value. Conclusion: Topical intra-lesional chitosan injection is effective for erosive OLP, which suggests that topical intra-lesional chitosan injection can be a promising therapeutic alternative for erosive OLP.