{"title":"程序性死亡配体1在骨肉瘤中的预后和临床病理意义:一项荟萃分析","authors":"Xiao-Bin Gu","doi":"10.31491/csrc.2019.06.031","DOIUrl":null,"url":null,"abstract":"Background: Programmed cell death-ligand 1 (PD-L1) was reported to be associated with survival outcomes in patients with osteosarcoma, but the results were controversial. This study aimed to evaluate the prognostic value of PD-L1 in osteosarcoma. Methods: The pooled HR and 95%CI were calculated to measure the prognostic role of PD-L1 for overall survival (OS) and disease-free survival (DFS). The odds ratio (OR) and 95%CI were used to evaluate the correlation of PD-L1 and clinicopathological features. Publication bias was measured using Begg’s funnel plots. Results: A total of 9 studies with 538 patients were included in this meta-analysis. The pooled results were HR=1.78, 95%CI=1.36-2.32, p<0.001 for OS and HR=1.24, 95%CI=0.31-5.07, p=0.761 for DFS. PD-L1 was significantly associated with metastasis (OR=8.51, 95%CI=4.3-16.86, p<0.001). Conclusion: PD-L1 might be a potential prognostic marker in patients with osteosarcoma. Keywords: meta-analysis; PD-L1; osteosarcoma; prognosis","PeriodicalId":158678,"journal":{"name":"Clinical Surgery Research Communications","volume":"75 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prognostic and Clinicopathological Significance of Programmed Death-Ligand 1 in Osteosarcoma: a Meta-Analysis\",\"authors\":\"Xiao-Bin Gu\",\"doi\":\"10.31491/csrc.2019.06.031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Programmed cell death-ligand 1 (PD-L1) was reported to be associated with survival outcomes in patients with osteosarcoma, but the results were controversial. This study aimed to evaluate the prognostic value of PD-L1 in osteosarcoma. Methods: The pooled HR and 95%CI were calculated to measure the prognostic role of PD-L1 for overall survival (OS) and disease-free survival (DFS). The odds ratio (OR) and 95%CI were used to evaluate the correlation of PD-L1 and clinicopathological features. Publication bias was measured using Begg’s funnel plots. Results: A total of 9 studies with 538 patients were included in this meta-analysis. The pooled results were HR=1.78, 95%CI=1.36-2.32, p<0.001 for OS and HR=1.24, 95%CI=0.31-5.07, p=0.761 for DFS. PD-L1 was significantly associated with metastasis (OR=8.51, 95%CI=4.3-16.86, p<0.001). Conclusion: PD-L1 might be a potential prognostic marker in patients with osteosarcoma. Keywords: meta-analysis; PD-L1; osteosarcoma; prognosis\",\"PeriodicalId\":158678,\"journal\":{\"name\":\"Clinical Surgery Research Communications\",\"volume\":\"75 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Surgery Research Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31491/csrc.2019.06.031\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Surgery Research Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31491/csrc.2019.06.031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Prognostic and Clinicopathological Significance of Programmed Death-Ligand 1 in Osteosarcoma: a Meta-Analysis
Background: Programmed cell death-ligand 1 (PD-L1) was reported to be associated with survival outcomes in patients with osteosarcoma, but the results were controversial. This study aimed to evaluate the prognostic value of PD-L1 in osteosarcoma. Methods: The pooled HR and 95%CI were calculated to measure the prognostic role of PD-L1 for overall survival (OS) and disease-free survival (DFS). The odds ratio (OR) and 95%CI were used to evaluate the correlation of PD-L1 and clinicopathological features. Publication bias was measured using Begg’s funnel plots. Results: A total of 9 studies with 538 patients were included in this meta-analysis. The pooled results were HR=1.78, 95%CI=1.36-2.32, p<0.001 for OS and HR=1.24, 95%CI=0.31-5.07, p=0.761 for DFS. PD-L1 was significantly associated with metastasis (OR=8.51, 95%CI=4.3-16.86, p<0.001). Conclusion: PD-L1 might be a potential prognostic marker in patients with osteosarcoma. Keywords: meta-analysis; PD-L1; osteosarcoma; prognosis
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