从间日疟原虫中吸取的经验教训有助于控制和消除疟疾

Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI:10.35259/isi.sact.2019_32722

P. Nogueira, Elizangela Farias

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引用次数: 0

摘要

方法:基于MSP1单倍型的寄生虫定量和基因分型，使用新一代测序，并与针对广泛的Block 2 PvMSP1肽的单倍型特异性血清学进行比较。基于同种型、亚类和亲和力谱的体液反应，对一组重组蛋白PvMSP1，如MSP1-19、n端PvMSP1和一组Block 2 PvMSP1变体。

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Lessons learnt from the Plasmodium vivax MSP1 towards malaria control and elimination efforts

Methodology: The quantification and genotyping of parasite based on MSP1 haplotypes using the new generation sequencing and comparison with a haplotype-specific serology against a broad set of Block 2 PvMSP1 peptides. The humoral response based on isotype, subclass and avidity profiles against a set of recombinant proteins PvMSP1, such as MSP1-19, N-terminal PvMSP1 and set of Block 2 PvMSP1 variants.

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Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos

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