苯并咪唑:药理学概况

Mahender Thatikayala, Anil Kumar Garige, Hemalatha Gadegoni
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引用次数: 0

摘要

苯并咪唑是一种双环杂环芳香族化合物,其中苯与咪唑部分熔合。苯并咪唑在药物化学领域占有重要地位,它具有多种药理活性,如抗菌、抗癌、抗真菌、抗利什曼原虫、抗结核、抗病毒和抗疟疾等,因此苯并咪唑部分吸引着药物化学家合成各种具有多种药理活性的苯并咪唑衍生物。本章主要讨论了最近合成的苯并咪唑类衍生物的抗癌、抗HIV、抗利什曼原虫和抗结核活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Benzimidazole: Pharmacological Profile
Benzimidazole is a bicyclic heterocyclic aromatic compound in which benzene fused to imidazole moiety. Benzimidazole holds a vital role in the field of medicinal chemistry which possesses wide variety of pharmacological activities like antibacterial, anti cancer, antifungal, antileishmanial, anti tubercular, anti viral and anti malarial respectively, hence the benzimidazole moiety attracting the medicinal chemist to synthesize the different benzimidazole derivatives with wide variety of pharmacological activities. The book chapter mainly discussed the anti cancer, anti HIV, antileishmanial and anti tubercular activites of recently synthesized benzimidazole derivatives.
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