Effects of hybrid non-linear feature extraction method on different data sampling techniques for liver disease prediction

Liver disease indicates inflammatory condition of the liver, liver cirrhosis, cancer, or an overload of toxic substances. A liver transplant may reinstate and extend life if a patient has severe liver disease. In the last few years, machine learning (ML) based diagnosis systems have played a vital role in assessing liver patients which eventually leads to proper treatment and saves human life. In this study, we try to predict liver patients by adopting a hybrid feature extraction method to enhance the performance of the ML algorithm. Medical data frequently exhibits non-linear patterns and class imbalances. This is undesirable for the majority of ML algorithms and degrades performance. Here, we present a hybrid feature space that combines t-SNE, Isomap nonlinear features, and kernel principal components that can explain 90% of the variation in the data as a solution to this issue. Before feeding the ML model, data preprocessing techniques including class balancing, identifying outliers, and impute missing values are used. A simulation study and ensemble learning also conducted to justify the proposed prediction performances. Our suggested hybrid non-linear feature exhibits a 2-20 % improvement over existing studies and the ensemble classifier achieved an ideal and outstanding accuracy of 91.33 %.