{"title":"基于成熟的儿童抗菌化疗药代动力学研究","authors":"Y. Tsuji","doi":"10.4058/jsei.36.77","DOIUrl":null,"url":null,"abstract":"Numerically, the most significant difference between children and adults is body weight. Hu-mans are not born with complete physiological functions, and our body functions mature with growth. Assuming adult renal function to be 100%, glomerular filtration rate only reaches approximately 25%-40% of adult function at birth. Renal function reaches approximately 90% of adult function in the first year after birth and is comparable to adult function in the second year after birth. This review will discuss energy metabolism of living organisms, maturation from children to adults, pharmacokinetics in children, and describes antimicrobial chemotherapy in children.","PeriodicalId":414784,"journal":{"name":"Japanese Journal of Infection Prevention and Control","volume":"27 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pharmacokinetics of Antimicrobial Chemotherapy Based on Maturation in Children\",\"authors\":\"Y. Tsuji\",\"doi\":\"10.4058/jsei.36.77\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Numerically, the most significant difference between children and adults is body weight. Hu-mans are not born with complete physiological functions, and our body functions mature with growth. Assuming adult renal function to be 100%, glomerular filtration rate only reaches approximately 25%-40% of adult function at birth. Renal function reaches approximately 90% of adult function in the first year after birth and is comparable to adult function in the second year after birth. This review will discuss energy metabolism of living organisms, maturation from children to adults, pharmacokinetics in children, and describes antimicrobial chemotherapy in children.\",\"PeriodicalId\":414784,\"journal\":{\"name\":\"Japanese Journal of Infection Prevention and Control\",\"volume\":\"27 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Japanese Journal of Infection Prevention and Control\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4058/jsei.36.77\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese Journal of Infection Prevention and Control","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4058/jsei.36.77","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pharmacokinetics of Antimicrobial Chemotherapy Based on Maturation in Children
Numerically, the most significant difference between children and adults is body weight. Hu-mans are not born with complete physiological functions, and our body functions mature with growth. Assuming adult renal function to be 100%, glomerular filtration rate only reaches approximately 25%-40% of adult function at birth. Renal function reaches approximately 90% of adult function in the first year after birth and is comparable to adult function in the second year after birth. This review will discuss energy metabolism of living organisms, maturation from children to adults, pharmacokinetics in children, and describes antimicrobial chemotherapy in children.
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