单极和双极系统射频消融过程的比较

V. Makarov, N. Boos
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引用次数: 0

摘要

大多数制造的射频消融装置使用插入肿瘤的单个电极进行加热。为了增加加热的体积,它们从内部冷却,有些还有一个用盐水湿润电极外表面的系统。对于直径超过3厘米的肿瘤坏死的需求促使我们寻找其他设计方案,以显著增加加热组织的体积。一开始,这些尝试是通过在肿瘤中打开额外的电线来增加肿瘤内部的热源数量,然后转变开始将电极数量增加到三个,并增加每个电极上的工作区域数量。结果,加热时间为45分钟,加热体积达到90立方厘米。一项关于射频消融的科技文献研究表明,生产烧蚀装置的外国公司已经认识到用双极多极装置取代单极电极的必要性。其原因不仅是使用双极电极具有更好的术后特性,而且除了肿瘤学外,还出现了新的消融应用领域,在治疗过程中使用更复杂形式的热场,例如管状坏死区。增加混凝体积的根本解决方案是从单极单电极到双极多电极设计的转变。在这种情况下,电场集中在电极之间的区域,整个肿瘤体积的加热效率显著提高,包括周围部分。最有效的方法是将双极电极合并成一个圆形簇,允许所有电极同时工作。在超声扫描仪的控制下,插入4到12个电极,在双极模式下工作。已经开发了一个模型,并设计了一个四电极簇,它允许在双极模式下对肿瘤进行分布式加热。由于进行了研究,发现双极系统的使用允许:由于增加肿瘤供电的可能性,可以显着增加坏死区域的体积;通过获得形状最接近所需的温度场,减少肿瘤体积上加热的不均匀性;通过在肿瘤外放置电极(“NO TOUCH”模式)来提高患者存活率。所进行的工作表明,通过增加电极的数量并沿着肿瘤体积靠近周围(包括损伤区)放置电极,可以显著增加被破坏组织的体积,这在技术上是可能的。因此,无需将电极与肿瘤接触,就可以从肿瘤周围加热肿瘤。热源数量的增加使得不仅可以减少电极上的负荷,而且可以缩短操作时间。大体积的烧蚀不可避免地增加了多电极系统中电极的数量,这导致了它们与发电机连接的复杂性。到目前为止,如何减小发电机负载的总阻抗仍然是一个未解决的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of radiofrequency ablation processes for monopolar and bipolar systems
Most of the manufactured radiofrequency ablation devices use single electrodes inserted into the tumor for heating. In order to increase the volume of heating, they are cooled from the inside, and some have a system for wetting the outer surface of the electrode with saline. The need for necrosis of tumors with a diameter of more than 3 cm made us look for other design solutions that would significantly increase the volume of heated tissue. At the beginning, these were attempts to increase the number of heat sources inside the tumor by opening additional wires in the tumor, then the transition began to increase the number of electrodes to three and increase the number of working zones on each electrode. As a result, heating volumes of 90 cm3 were achieved with a heating time of 45 min. A study of the scientific and technical literature on RFA showed that foreign firms producing ablation devices already understand the need to replace monopolar electrodes with bipolar multi-electrode devices. The reason for this is not only the better postoperative characteristics of the use of bipolar electrodes, but also the emergence, in addition to oncology, of new areas of ablation application, where more complex forms of thermal fields are used during therapy, for example, tubular zones of necrosis. A radical solution to the problem of increasing the volume of coagulation is the transition from monopolar single electrodes to bipolar multielectrode designs. In this case, the electric field is concentrated in the areas between the electrodes and the heating efficiency increases significantly throughout the tumor volume, including the peripheral part. The most effective way is to incorporate bipolar electrodes into a circular cluster, allowing all electrodes to work simultaneously. Under the control of an ultrasound scanner, 4 to 12 electrodes are inserted, operating in bipolar mode. A model has been developed and the design of a four-electrode cluster has been developed, which allows for distributed heating of the tumor in a bipolar mode. As a result of the studies carried out, it was found that the use of bipolar systems allows: to significantly increase the volume of the area of necrosis due to the possibility of increasing the power supplied to the tumor; to reduce the unevenness of heating over the volume of the tumor by obtaining temperature fields, the shape of which is closest to the required one; improve patient survival rates by placing electrodes outside the tumor (“NO TOUCH” mode). The work performed indicates the technical possibility of a significant increase in the volume of destroyed tissue by increasing the number of electrodes and placing electrodes along the tumor volume closer to the periphery, including the ablastic zone. As a result, it became possible to heat tumors from their periphery without contacting the electrodes with the tumor. The increase in the number of heat sources made it possible not only to reduce the load on the electrodes, but also to shorten the procedure time. Ablation of large volumes entailed an inevitable increase in the number of electrodes in a multi-electrode system, which led to the complication of their connection to the generator. So far, an unresolved problem remains to reduce the total impedance of the generator load.
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