传统药物:免疫抑制剂和皮质类固醇治疗炎症性肠病的机制

C. R. B. Cardoso, Amanda de Castro Habka, C. Pinzan, Camilla N. S. Oliveira, Jefferson Luiz da Silva, M. Duarte-Silva
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引用次数: 1

摘要

炎症性肠病(IBD)如克罗恩病和溃疡性结肠炎是胃肠道的免疫功能障碍,由于多因素过程而发展,包括易感受试者的遗传易感性、肠道生态失调和过度炎症。这些疾病影响着全世界数百万人,对医疗保健系统和患者的生活质量产生重大影响。考虑到IBD表现的基础是慢性炎症,主要的治疗选择是通过免疫抑制和调节治疗来控制患者的炎症反应。因此,在本章中,我们回顾了与抑制粘膜免疫的治疗相关的主要机制以及皮质类固醇治疗在克罗恩病和溃疡性结肠炎中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Traditional Drugs: Mechanisms of Immunosuppressor and Corticosteroid Therapies for Inflammatory Bowel Diseases
The inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis are immunological dysfunctions of the gastrointestinal tract that develop because of multifactorial processes, including genetic predisposition, gut dysbio-sis, and excessive inflammation in susceptible subjects. These pathologies affect millions of people worldwide, with substantial impact on healthcare systems and patients’ quality of life. Considering the chronic inflammation that underlies the IBD presentation, the main treatment options are related to the control of patients’ inflammatory response, through immunosuppressor and modulatory therapies. Therefore, in this chapter we reviewed the main mechanisms associated with the treatments that are aimed at suppressing mucosal immunity and the effects of corticosteroid therapies in Crohn’s disease and ulcerative colitis.
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