NLR和d -二聚体联合作为COVID-19严重程度的预测工具

Shofia Widya Murti, D. Prihatni, A. Sugianli
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引用次数: 1

摘要

冠状病毒病-19 (COVID-19)是由严重急性呼吸综合征-冠状病毒-2 (SARS-CoV-2)引起的。在严重的情况下,免疫反应可能引起细胞因子风暴。中性粒细胞淋巴细胞比率(NLR)和d -二聚体是可用于预测COVID-19严重程度的参数。本研究旨在确定NLR联合d -二聚体对COVID-19患者严重程度的诊断有效性。研究人群为实时荧光定量pcr确诊的住院COVID-19患者。这是一项回顾性横断面研究。截断值基于受试者算子特征曲线(ROC)分析的曲线下面积(AUC),并通过评估敏感性、特异性、阳性预测值(PPV)、阴性预测值(NPV)、阳性似然比(LR+)和阴性似然比(LR-),对重症和非重症COVID-19组进行NLR和d -二聚体联合效度检验。共有1314名受试者。744人在严重组,570人在非严重组。NLR > 4.02和d -二聚体> 1.12 mg/L对COVID-19严重程度的敏感性值为70.8%,特异性值为98.3%,PPV为98.1%,NPV为72.1%,LR+ 40.38和LR- 0.30。NLR >4.02和d -二聚体>1.12 mg/L对COVID-19严重程度的特异性和PPV均较高(分别为98.3%和98.1%)。LR+值也支持了这一点,即NLR > 4.02, d -二聚体> 1.12 mg/L时,与NLR ≥4.02,d -二聚体≥1.12 mg/L相比,可能导致严重COVID-19的几率是NLR的40.38倍。NLR与d -二聚体联合可用于预测COVID-19的严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Combination of NLR and D-dimer as Predictor Instrument for the Severity of COVID-19
Coronavirus Disease-19 (COVID-19) is caused by Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2). In severe cases, the immune response may cause a cytokine storm. Neutrophil Lymphocyte Ratio (NLR) and D-dimer are parameters that may be used to predict the severity of COVID-19. This study aims to determine the diagnostic validity of the combination of NLR and D-dimer on the severity of COVID-19 patients. The study population was hospitalized COVID-19 patients whose diagnosis were confirmed by real time-PCR. This was a retrospective cross-sectional study. The cut-off value was based on the Area Under Curve (AUC) of the Receiver Operator Characteristic Curve (ROC) analysis and the combination of NLR and D-Dimer validity was tested against the severe and non-severe COVID-19 groups by assessing sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), positive Likelihood Ratio (LR+) and negative Likelihood Ratio (LR-). There were 1,314 subjects. Seven hundred and forty-four were in the severe group, 570 in the non-severe group. The combination of NLR > 4.02 and D-dimer > 1.12 mg/L on the severity of COVID-19 showed a sensitivity value of 70.8%, specificity 98.3%, PPV 98.1%, NPV 72.1%, LR+ 40.38 and LR- 0.30. The combination of NLR >4.02 and D-dimer >1.12 mg/L for the severity of COVID-19 showed high specificity and PPV (98.3% and 98.1%). This was also supported by the LR+ value, which indicates that if NLR > 4.02 and D-dimer > 1.12 mg/L, it may cause severe COVID-19 by 40.38 times compared to NLR ≤4.02, and D-dimer ≤1.12 mg/L. The combination of NLR and D-Dimer can be used to predict the severity of COVID-19.
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