成人创伤患者血栓预防药物的时机和剂量

M. Bawazeer, M. Amer, K. Maghrabi, R. Amin, E. De Vol, M. Hijazi
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引用次数: 1

摘要

药物静脉血栓栓塞预防在创伤人群被认为是一个真正的挑战。诸如开始治疗的理想时间、药物的类型和剂量以及如何监测这些患者等问题都存在争议。我们检索了PUBMED, EMBASE和COCHRANE数据库。我们还从主要综述文章和最新指南中提取了参考文献。在创伤性脑损伤、脊髓损伤(SCI)和实体器官损伤患者中,开始血栓栓塞预防的时机在文献中没有很好的定义。这是因为相关的出血风险。同时,化学预防的种类和剂量也没有很好地界定。在这篇综述中,我们介绍了关于这一主题的最新研究。我们讨论了争议的领域和开始化学预防背后的挑战。我们还讨论了通过沙特重症监护试验组进行多中心研究的未来研究潜力领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Timing and dose of pharmacological thromboprophylaxis in adult trauma patients
Pharmacological venous thromboembolism prophylaxis in the trauma population is considered a real challenge. Issues like the ideal time to start therapy, type and dose of the medication, and how to monitor these patients are controversial. We searched PUBMED, EMBASE, and COCHRANE Databases. We also extracted the references from major review articles and recent guidelines. The timing to start thromboembolic prophylaxis in patients with traumatic brain injuries, Spinal Cord Injuries (SCI), and solid organ injuries is not very well defined in the literature. This is because of the associated bleeding risk. At the same time, the type of chemical prophylaxis and dose are not well defined as well. In this review, we present the most up to date studies done on this topic. We discuss the areas of controversy and the challenges behind starting chemical prophylaxis. We also discuss areas of future research potentials to do multicenter studies through the Saudi Critical Care Trials Group.
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