{"title":"干细胞的氧气供应和自我更新","authors":"Z. Ivanovic","doi":"10.1109/AT-EQUAL.2009.24","DOIUrl":null,"url":null,"abstract":"The relationship between stem cells and micro-environmental/culture oxygenation has been reviewed. The basic principle of stem cell biology, “the generation-age hypothesis”, and hypoxic metabolic properties of stem cells are considered in the context of the oxygen-dependent evolution of life and its transposition to ontogenesis and development. A hypothesis relating the self-renewal with the anaerobic and hypoxic metabolic properties of stem cells and the actual O2 availability is elaborated (“oxygen stem cell paradigm”). The revision of our knowledge on cell/cytokine physiology, which has been acquired ex-vivo at non physiological atmospheric (20-21%) O2 concentrations representing a hyperoxic state for most primate cells, has thus become imperious for an adequate approach to cell engineering.","PeriodicalId":407640,"journal":{"name":"2009 Advanced Technologies for Enhanced Quality of Life","volume":"72 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2009-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Oxygen Availability and Self Renewal of Stem Cells\",\"authors\":\"Z. Ivanovic\",\"doi\":\"10.1109/AT-EQUAL.2009.24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The relationship between stem cells and micro-environmental/culture oxygenation has been reviewed. The basic principle of stem cell biology, “the generation-age hypothesis”, and hypoxic metabolic properties of stem cells are considered in the context of the oxygen-dependent evolution of life and its transposition to ontogenesis and development. A hypothesis relating the self-renewal with the anaerobic and hypoxic metabolic properties of stem cells and the actual O2 availability is elaborated (“oxygen stem cell paradigm”). The revision of our knowledge on cell/cytokine physiology, which has been acquired ex-vivo at non physiological atmospheric (20-21%) O2 concentrations representing a hyperoxic state for most primate cells, has thus become imperious for an adequate approach to cell engineering.\",\"PeriodicalId\":407640,\"journal\":{\"name\":\"2009 Advanced Technologies for Enhanced Quality of Life\",\"volume\":\"72 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2009 Advanced Technologies for Enhanced Quality of Life\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/AT-EQUAL.2009.24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2009 Advanced Technologies for Enhanced Quality of Life","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/AT-EQUAL.2009.24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Oxygen Availability and Self Renewal of Stem Cells
The relationship between stem cells and micro-environmental/culture oxygenation has been reviewed. The basic principle of stem cell biology, “the generation-age hypothesis”, and hypoxic metabolic properties of stem cells are considered in the context of the oxygen-dependent evolution of life and its transposition to ontogenesis and development. A hypothesis relating the self-renewal with the anaerobic and hypoxic metabolic properties of stem cells and the actual O2 availability is elaborated (“oxygen stem cell paradigm”). The revision of our knowledge on cell/cytokine physiology, which has been acquired ex-vivo at non physiological atmospheric (20-21%) O2 concentrations representing a hyperoxic state for most primate cells, has thus become imperious for an adequate approach to cell engineering.
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