上皮肿瘤在间质转化过程中的代谢特征

E. Bakurova
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摘要

不同部位的上皮性肿瘤都能产生活性氧,刺激其上皮间质转化。对于非小细胞肺癌(NSCLC)、胃和肠腺癌(GIAC)的肿瘤,它们的代谢异质性得到了证实。通过对同一定位的形态学同质肿瘤的分析结果,我们发现了以黄嘌呤氧化酶、超氧化物歧化酶活性升高、谷胱甘肽过氧化物酶活性降低为特征的肿瘤集群(与病理呈负相关(ρ = -0,465, p < 0.05))。因此,谷胱甘肽过氧化物酶活性在第二个GIAC簇中最低,比相应簇的NSCLC肿瘤低1.4倍,在第一个簇中低1.8倍。在第二个NSCLC集群中,它比第一个集群低1.5倍。在此背景下,第二组肿瘤中不同部位的超氧化物歧化酶活性在NSCLC和GIAC中分别增加了2倍和1.7倍。它会导致肿瘤中过氧化氢的产生增加。腺苷脱氨酶活性升高(正强相关(Spearman秩相关系数ρ = 0,805, p < 0.01))可能伴随着腺苷水平的降低及其抑制肿瘤侵袭性的调节作用。建立了酶活性与病理的相关性。在不同定位的肿瘤中,揭示了代谢刺激肿瘤上皮-间质转化的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
THE EPITHELIAL TUMOR METABOLISM FEATURES DURING ITS MESENCHYMAL TRANSITION
The epithelial tumors of various localizations are capable of producing reactive oxygen species that stimulate their epithelial-mesenchymal transformation. For tumors of non-small cell lung cancer (NSCLC), gastric and intestinal adenocarcinomas (GIAC) their metabolic heterogeneity was established. By the results of analysis in morphologically homogeneous tumors of the same localization we detected clusters of tumors characterized by increased activity of xanthine oxidase, superoxide dismutase, decreased activity of glutathione peroxidase (negative relation with pathology (ρ = -0,465, p < 0,05)). Thus, glutathione peroxidase activity was minimal in the second GIAC cluster, 1.4-fold lower, and 1.8-fold lower in their first cluster than in NSCLC tumors of the corresponding clusters. In the second NSCLC cluster, it was 1.5-fold lower than in their first cluster. Against this background, superoxide dismutase activity in tumors of different localizations included in the second clusters, on the contrary, increased 2-fold in NSCLC and 1.7-fold in GIAC, respectively. It leads to increased production of hydrogen peroxide in the tumor. Increase of adenosine deaminase activity detected (positive strong correlation (Spearman rank correlation coefficient ρ = 0,805, p < 0.01)) may be accompanied by a decrease of adenosine levels and its regulatory effects preventing tumor aggressive properties. Correlation of enzymatic activity with pathology was established. In different localization tumors the possibility of metabolic stimulation of tumor epithelial-mesenchymal transformation was revealed.
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