F. Çoban, Binnaz Kuru
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引用次数: 1

摘要

本研究旨在探讨对乙酰氨基酚肝毒性模型中总抗氧化能力水平、微量元素水平和蛋白质羰基水平与硼作用的关系。我们研究了硼的功效和抗氧化作用,硼具有保护组织中氧化/抗氧化系统和增加谷胱甘肽储备的特点,可以减少对乙酰氨基酚的负面影响,而对乙酰氨基酚是已知的引起广泛和高剂量的肝毒性损伤。微量元素是人体必需的物质,含量很少。除了辅酶的作用外,还有许多酶所必需的功能。实验动物分为7组:对照组、2g /kg扑热息痛、2g /kg扑热息痛+ 50 mg/kg硼酸、2g /kg扑热息痛+ 100 mg/kg硼酸、2g /kg扑热息痛+ 200 mg/kg硼酸、2g /kg扑热息痛+ 140 mg/kg n -乙酰半胱氨酸200 mg/kg硼酸。结果表明,血清对乙酰氨基酚天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)水平及分析结果表明,组织样品中蛋白质羰基(POC)、总氧化剂水平(TOS)和氧化应激指数(OSI)水平均升高,硼给药组显著降低。对乙酰氨基酚组蛋白质硫醇(p - sh)、总抗氧化剂水平(TAS)和微量元素水平降低,硼组显著(p<0.05)升高。对乙酰氨基酚组微量元素(Mg、Cu、Zn、Se)水平显著低于对照组(p<0.05),补硼组微量元素(Mg、Cu、Zn、Se)水平显著高于对乙酰氨基酚组(p<0.05)。结果表明,对乙酰氨基酚对氧化/抗氧化平衡的破坏随补硼量的增加而减小,硼对不同参数的影响表明硼具有抗氧化性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EFFECT OF BORON ON TRACE ELEMENT LEVEL İN PARACETAMOL INDUCED HEPATOTOXİCİTY MODEL
In this study, we have aimed to determine the relationship between the levels of total antioxidant-oxidant capacity, trace elements and protein carbonyl levels in paracetamol induced hepatotoxicity model and the effect of boron. We investigated the efficacy and antioxidant role of boron, which has the characteristics of protecting the oxidant/ antioxidant system in tissues and increasing the glutathione depots, in reducing the negative effects of paracetamol which is known to cause widespread and high doses of hepatotoxic damage. Trace elements are essential substances for the human body and are found in small amounts. In addition to the role of cofactors in many enzymes, also required for function. The experimental animals used in our study were divided into seven groups: Control, 2 g/kg paracetamol, 2 g/kg paracetamol + 50 mg/kg boric acid, 2 g/kg paracetamol + 100 mg/kg boric acid, 2 g/kg paracetamol + 200 mg/kg boric acid, 2 g/kg paracetamol + 140 mg/kg N-acetylcysteine 200 mg/kg boric acid. As a result of the measurements, serum paracetamol aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels and analysis of tissue samples as a result of protein carbonyl (POC), total oxidant level (TOS) and oxidative stress index (OSI) levels increased, boron given groups significant decrease was observed. Paracetamol group protein thiol (P-SH), total antioxidant level (TAS) and trace element levels decreased while there was a significant (p<0.05)  increase in boron groups. Trace element levels (Mg, Cu, Zn, Se) were significantly lower in paracetamol groups compared to control group (p<0.05) and Trace element levels (Mg, Cu, Zn, Se) were significantly (p<0.05)  increased boron supplement group compared to paracetemol group. As a result, we observed that the damage caused by the paracetamol to the oxidant / antioxidant balance decreased with boron supplementation and it can be said that the boron exhibits antioxidant properties based on its effects on different parameters.
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