{"title":"胃手术癌的发病机制——动物模型。","authors":"S Dittrich","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>An experimental study on rats was performed to observe pathogenetic factors causing cancerogenesis in operated stomach. In sets I and II without exogenous carcinogen exposition 450 rats were operated upon by a different methods. In groups I it was B II gastrectomy, B II with Braun's anastomosis, B II in Roux en Y modification, B I and B I with jejunal interposition. In group II non-resective methods were tested: gastroenterostomy, gastroenterostomy with Braun's anastomosis, gastroenterostomy in Roux en Y modification, and vagotomy with pyloroplasty. In the group III 147 rats with different gastric operations were submitted to oral nitrate and nitrate with ascorbic acid exposition. The results confirmed significant pathogenetic influence of enterogastric reflux on cancerogenesis in the operated stomach. Ascorbic acid added to the exogenous cancerogen leads to a suppression of development of gastric cancer in rats.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"35 1","pages":"149-61"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pathogenesis of carcinoma in operated stomach--an animal model.\",\"authors\":\"S Dittrich\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>An experimental study on rats was performed to observe pathogenetic factors causing cancerogenesis in operated stomach. In sets I and II without exogenous carcinogen exposition 450 rats were operated upon by a different methods. In groups I it was B II gastrectomy, B II with Braun's anastomosis, B II in Roux en Y modification, B I and B I with jejunal interposition. In group II non-resective methods were tested: gastroenterostomy, gastroenterostomy with Braun's anastomosis, gastroenterostomy in Roux en Y modification, and vagotomy with pyloroplasty. In the group III 147 rats with different gastric operations were submitted to oral nitrate and nitrate with ascorbic acid exposition. The results confirmed significant pathogenetic influence of enterogastric reflux on cancerogenesis in the operated stomach. Ascorbic acid added to the exogenous cancerogen leads to a suppression of development of gastric cancer in rats.</p>\",\"PeriodicalId\":21432,\"journal\":{\"name\":\"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove\",\"volume\":\"35 1\",\"pages\":\"149-61\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
以大鼠为实验对象，观察手术胃癌变的致病因素。在没有外源性致癌物暴露的第一组和第二组，用不同的方法对450只大鼠进行手术。I组为B - II胃切除术，B - II Braun吻合，B - II Roux en Y改良，B - I和B - I空肠间置。II组采用非切除方法:胃肠造口术、Braun吻合的胃肠造口术、Roux en Y改良的胃肠造口术、迷走神经切开术合并幽门成形术。III组147只胃手术大鼠分别口服硝酸根和硝酸根加抗坏血酸。结果证实肠胃反流对手术胃癌变有显著的病理影响。在外源性致癌物中加入抗坏血酸可抑制大鼠胃癌的发生。
Pathogenesis of carcinoma in operated stomach--an animal model.
An experimental study on rats was performed to observe pathogenetic factors causing cancerogenesis in operated stomach. In sets I and II without exogenous carcinogen exposition 450 rats were operated upon by a different methods. In groups I it was B II gastrectomy, B II with Braun's anastomosis, B II in Roux en Y modification, B I and B I with jejunal interposition. In group II non-resective methods were tested: gastroenterostomy, gastroenterostomy with Braun's anastomosis, gastroenterostomy in Roux en Y modification, and vagotomy with pyloroplasty. In the group III 147 rats with different gastric operations were submitted to oral nitrate and nitrate with ascorbic acid exposition. The results confirmed significant pathogenetic influence of enterogastric reflux on cancerogenesis in the operated stomach. Ascorbic acid added to the exogenous cancerogen leads to a suppression of development of gastric cancer in rats.
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