血液学和炎症标志物在肉芽肿性和非肉芽肿性淋巴结炎中的作用

Faiyaz Ahmad, Faiza Samin, Ankita Mittal, S. Awasthi, Ariba Nasir
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引用次数: 0

摘要

由于各种感染,如肺结核和淋巴细胞增生性疾病,淋巴结内淋巴细胞增加,可导致淋巴结病。肉芽肿性淋巴结炎引起炎症生物标志物增加,可通过使用TLC和DLC的简单血象及其衍生的比率(如NLR(中性粒细胞淋巴细胞比率)和PLR(血小板淋巴细胞比率)进行评估。建立血液学和炎症生物标志物在肉芽肿性和非肉芽肿性淋巴结炎中的作用。该研究于2020年8月至2022年9月在一家三级保健中心进行。该研究纳入了150例颈部肿块患者,并考虑了纳入和排除标准。细胞学证实的病例根据细胞学评估分为肉芽肿和非肉芽肿病例。采用TLC、DLC、ESR、CRP、NLR、PLR等不同实验室参数对肉芽肿性淋巴结炎与非肉芽肿性淋巴结炎进行比较。在研究人群中,女性有92人(61.3%),男性有58人(38.7%),但与非肉芽肿性淋巴结炎组相比,女性以70.7%的血液学标志物为主,如NLR、PLR和CRP在肉芽肿性淋巴结炎组中明显更高。中性粒细胞在肉芽肿性淋巴结炎中明显增高,而在非肉芽肿性淋巴结炎中,淋巴细胞明显增高。肺结核是我们地区与颈淋巴肿大有关的最常见的临床病症。通常情况下,女性也参与其中。NLR、PLR、CRP等血液学和生化指标可在FNAC前提示肉芽肿性和非肉芽肿性淋巴结炎的存在。它将帮助治疗医生有条不紊地思考早期病例识别,避免在结核病等情况下的诊断延误,特别是在初级保健一级。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of hematological and inflammatory marker in granulomatous compared to non-granulomatous lymphadenitis
Lymphadenopathy can result due to an increase in lymphocytes in the lymph node due to various infections like tuberculosis and lymphoproliferative conditions. Granulomatous lymphadenitis causes an increase in inflammatory biomarkers which can be assessed by simple hemogram using TLC and DLC and ratios derived from it like NLR (Neutrophil Lymphocyte Ratio) and PLR (Platelet Lymphocyte Ratio). To establish the role of hematological and inflammatory biomarkers in granulomatous and non-granulomatous lymphadenitis.The study was performed in a tertiary care center from august 2020 to September 2022. The study included 150 patients with neck mass taking inclusion and exclusion criteria into account. Cytologically proven cases were categorised into granulomatous and non-granulomatous cases depending on cytological evaluation. Different laboratory parameters like TLC, DLC, ESR, CRP, NLR, and PLR were used to compare granulomatous lymphadenitis to non-granulomatous.In the studied population there were 92(61.3%) females and 58(38.7%) males but when compared to the non-granulomatous lymphadenitis group, females predominated by 70.7% hematological markers like NLR, PLR, and CRP in the granulomatous lymphadenitis group was significantly higher. The mean Neutrophil was considerably higher among granulomatous lymphadenitis but in non-granulomatous lymphadenitis, the group showed considerably greater mean lymphocytes.Tuberculosis is the most frequent clinical condition connected to cervical lymphadenopathy in our area. More often than not, women are involved. Hematological and biochemical parameters like NLR, PLR, and CRP can give us some indication before FNAC for the presence of granulomatous and non-granulomatous lymphadenitis. It will help the treating doctor think methodically about early case identification and avoid diagnostic delays in situations like tuberculosis, especially at the primary care level.
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