早期肺癌假肺脓肿腔病变的手术,病例报告。

Eddyn Ruben Macías, Diana Margarita Iñahuazo, Diana Elizabeth Peñaloza, María de Lourdes Garcés
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引用次数: 0

摘要

肺空化是指肺实变区、肿块或结节内充满空气的空间,由病变坏死部分经支气管树排出或排出而产生。最常见的原因是结核中的分枝杆菌感染,或坏死性肺炎、肺脓肿中的细菌感染,尽管在极少数情况下,它也可能出现在梗死的肺栓塞中。应始终怀疑肿瘤,如鳞状细胞癌,它与肺腔病变的关系较大,与腺癌的关系较小。其他不常见的原因是肉芽肿病合并多血管炎、淋巴瘤、尘肺病、矽肺病。病例描述患者呼吸道症状演变一年,特征为咳嗽散发淡黄色咳痰并胸痛,2020年3月伴咯血、进行性呼吸困难,未见体重减轻、发热,私人医生提示抗生素部分改善;2020年8月,她出现咯血,再次去看医生并要求进行断层扫描,发现肺空化与实变相关的证据,给了新的抗生素方案,但没有改善,她于2020年11月去了这家诊所。新的断层扫描显示空化,壁厚,肾功能和肝功能保存,感染谱和免疫检查阴性。支气管镜检查BAL细胞学阳性,单纯体层扫描和PET扫描显示右下叶高代谢肿块,未见远处转移或淋巴结受累。评估肺功能以确定手术分辨率,如果足够,则行右下肺叶切除术,显示游离手术边缘,恶性区域淋巴结阴性,病理报告肺腺癌,病理分期T3N0,根据影像学研究M0确定分期IIB。他需要化疗和辅助放疗。肺癌的症状可以是沉默的,主要是非特异性的,Bradley等通过症状学和胸片研究肺癌的风险,他们认为胸片的敏感性有限,只有咯血对恶性肿瘤有统计学意义的预测价值。关于空化病变作为肺癌的一种表现,在所有患者中有5%至15%的病例得到证实。在原发性肿瘤中,我们观察到病变空化的频率与组织学亚型有关,在鳞状癌中较常见(9-38%),在腺癌和大细胞癌中较少见(6-15%),几乎排除了小细胞癌。综上所述,多学科管理使患者的诊断和治疗算法都有充分的定位,这将提高患者的生存率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CIRUGÍA DE CÁNCER DE PULMÓN EN ESTADIO TEMPRANO EN LESIÓN CAVITARIA QUE SIMULABA ABSCESO PULMONAR, REPORTE DE CASO.
Introduction Pulmonary cavitations are defined as a space filled with air, within a pulmonary area of consolidation, a mass or a nodule, they are produced by the expulsion or drainage of the necrotic part of the lesion through the bronchial tree. The most frequent causes are infectious by mycobacteria as in tuberculosis, or bacteria as in necrotizing pneumonia, pulmonary abscesses, although on rare occasions, it can also present in pulmonary embolism with infarction. Neoplasms should always be suspected, being squamous cell carcinoma the one that has been related to a greater extent to pulmonary cavitary lesion, and to a lesser extent to adenocarcinoma. Other less frequent causes are granulomatosis with polyangiitis, lymphomas, pneumoconiosis, silicosis. Case description Patient with respiratory symptoms of one year of evolution, characterized by cough with sporadic yellowish expectoration plus chest pain, in 03/2020 is accompanied by hemoptysis and progressive dyspnea, without weight loss or fever, private physician indicates antibiotic with partial improvement; On 08/2020 she presented hemoptysis, she went to the doctor again and requested a tomographic study in which she showed evidence of pulmonary cavitation associated with consolidation, a new antibiotic scheme was administered, without improvement, and she went to this clinic on 11/2020. New tomographic study showed cavitation with thick walls, preserved renal and hepatic function, infectious profile and negative immunological tests. Bronchoscopy with BAL cytology positive for malignancy, simple and contrasted body tomography and PET SCAN were indicated, showing hypermetabolic mass in the right lower lobe, with no evidence of distant metastasis or affected lymph nodes. Pulmonary function is assessed for surgical resolution, being adequate, right lower lobectomy is performed, showing free surgical edges, with negative regional nodes for malignancy, with pathology reporting lung adenocarcinoma, pathological staging T3N0, and according to the imaging study M0, determining stage IIB. He required chemotherapy and adjuvant radiotherapy. Conclusion Lung cancer symptomatology can be silent and mainly non-specific, in the study by Bradley et al. addressing lung cancer risk by symptomatology and by chest radiography, they conclude that chest radiography has limited sensitivity and that only hemoptysis has a statistically significant predictive value for malignancy. In relation to cavitated lesions as a presentation in lung cancer, they are evidenced in 5 to 15% of all patients. Within primary neoplasms the frequency with which we can observe cavitation of the lesion is related to the histological subtype, it is more frequent in squamous carcinomas (9-38%), rarer in adenocarcinomas (6-15%) and large cell carcinoma, and practically rules out small cell carcinoma. As conclusions, multidisciplinary management allows adequate orientation in both the diagnostic and therapeutic algorithm of patients, which will improve patient survival.
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