自由活动啮齿动物植入式电刺激系统用于DBS治疗

E. Kussener, J. Aguilar, O. Mainard, D. Goguenheim, G. Oudinet, P. Salin, C. Forni
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引用次数: 0

摘要

在过去的二十年里,人们提出了大量关于电刺激的解决方案,目的是治疗某些病理。他们依靠的原理是,对神经元、肌肉或其他内部神经的电刺激是可能的。在此背景下,本文提出了一种深部脑刺激器(DBS)的解决方案,旨在减少帕金森病的影响。本文介绍了单相和双相电刺激拓扑结构。采用0.35 μ m标准CMOS技术,开发了片上集成系统解决方案。硅芯片的尺寸为620 × 550¿m2,电池寿命延长约一周(比分立版本长十倍)。该电路有两个终端,通过两个电极直接连接到大脑上,另外两个终端连接到硬币电池(唯一非皮下部分)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Implantable electrostimulation system in freely moving rodent for DBS treatment
A large number of solutions on electrostimulation were proposed in the last twenty years with the aim of looking after certain pathologies. They rely on the principle that electrostimulation of a neuron, muscle or another internal nerve is possible. In this context, this paper presents a solution of deep brain stimulator (DBS) having for aim to reduce the influence of the Parkinson's disease. This paper presents monophasic and biphasic electrostimulation topologies. The integrated system on chip solution was developped on 0.35¿m standard CMOS technology. The silicon die possesses a size of 620x550¿m2, with an improved battery life of about a week (ten times longer than the discrete version). The circuit has two terminals directly connected on the brain via two electrodes and two terminals to be connected to the coin cell battery (the only non under cutaneous part).
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