羟基脲用于镰状细胞性贫血患者未充分利用,即使在全民卫生保健系统

Kirsten Miller-Jaster, Apryl Susi, Cade M. Nylund, K. Lieuw, Gregory H Gorman
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摘要

背景:镰状细胞性贫血(SCA)在美国是一种常见的血液病,影响着非洲裔美国人的严重发病率和死亡率。羟基脲是一种安全有效的药物,可减少缺血事件和终末器官损伤。在一项随机安慰剂对照试验(BABY HUG)中发现羟基脲对儿童有益,并于2014年被强烈推荐用于儿科。令人担忧的是,这种疗法现在被认为是标准治疗,但仍未得到充分利用。目的:我们的目的是描述……
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hydroxyurea Use for Sickle Cell Anemia Patients is Underutilized Even Within a Universal Health Care System
Background: Sickle cell anemia (SCA) is a common hematologic disease in the US which results in severe morbidity and mortality affecting the African American population. Hydroxyurea is a safe and efficacious drug that decreases ischemic events and end-organ damage. Hydroxyurea was found in a randomized placebo controlled trial (BABY HUG) to be beneficial to children and was strongly recommended for pediatric use in 2014. There is concern that this therapy, now considered standard of care, remains underutilized. Objective: We aim to describe …
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