Jessica B. Chang, Marc A. Soares, April M. Duckworth, Nakul Rao, Jonathan P. Massie, Camille Kim, Piul S. Rabbani, Daniel J Ceradini
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Ex Vivo Primed Mesenchymal Stem Cell Therapy Prevents Endothelial Failure and Enhances Allograft Perfusion
Endothelial failure following ischemia-reperfusion injury (IRI) in transplantation triggers the inflammatory cascade, compromising allograft perfusion and contributing to acute rejection. Culture conditions that activate the innate immunomodulatory phenotype of mesenchymal stem cells (MSCs) may attenuate IRI-mediated endothelial failure. We hypothesized that expansion in hypoxia or with inflammatory cytokines primes immunosuppressive functions of MSCs and improves allograft perfusion after ex-vivo delivery.
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