Kathleen P. Plotzke , Terushi Haradahira , Louis Stancato , Norman M. Olken , Scott Skinner , Milton D. Gross , Richard L. Wahl , Raymond E. Counsell
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Selective localization of radioiodinated alkylphosphocholine derivatives in tumors
We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m[125I]iodophenyl)dodecyl phosphocholine (NM-324) and hexadecyl-2-[N,N-dimethyl-N-(m[125I]iodobenzyl-ammonium]ethyl phosphate (NM-326) demonstrated the ability of such compounds to localize in and thereby visualize the Walker 256 tumor in rats. However, the tumor avidity of NM-324 was far superior to NM-326. In addition, NM-324 showed excellent tumor localization in athymic mice bearing subcutaneous human tumors.
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