新型福马甲酸衍生物:合成、表征、抗乳腺癌及抗氧化研究

Hasanain Gomhor, J. Alqaraghuli, Z. Y. Kadhim, A. Seewan, ضه .كٍبرىكسلأا
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引用次数: 0

摘要

合成了一种新型的福马甲酸(FOZ)衍生物,并对其作为抗乳腺癌和抗氧化剂进行了评价。用CHN、FT-IR、1H-NMR和质谱等方法证实了FOZ的化学结构。测定了FOZ对乳腺癌细胞的抗增殖活性。合成的化合物在MCF-7细胞中显示出显著的抗乳腺癌活性。MTT检测显示,16µg/ml的FOZ和标准药物阿霉素(Dox)在48h后对细胞生长的抑制作用分别为83.33%和92.66%。测定了不同浓度(25 ~ 400ug/ml)的福马嗪体外抗氧化活性,结果表明,400 μg/ml的福马嗪比抗坏血酸更有效
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel Formazan Derivative: Synthesis, Characterization, Anti-breast Cancer and Antioxidant Investigation
New formazan (FOZ) derivative was synthesized and evaluated as an anti-breast cancer and antioxidant agent. Chemical structure of FOZ was proved by CHN, FT-IR, 1H-NMR and Mass techniques. The anti-proliferative activity of FOZ was estimated toward breast cancer cells. The synthesized compound displayed significant anti-breast cancer activity towered MCF-7 cells. The MTT examination demonstrated that 16 µg/ml of FOZ and doxorubicin (Dox) as a standard drug suppressed cell growth by 83.33% and 92.66%, respectively after 48hrs. The formazan antioxidant activity was estimated in vitro at various concentrations (25-400ug/ml) and the outcomes showed that 400 μg/ml of FOZ was more efficient compared to ascorbic acid
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