Applications of Magnetic Nanoparticles in Hyperthermia and its Characterization Studies

Magnetic hyperthermia is considered as a therapeutic way since they exhibit hysteresis property and dissipate heat when placed under the magnetic flux area. As per ampere's law, the sum of elements in the magnetic field is equal to the permeability in the electric current enclosed in the loop area. Thus, it transforms high frequency electromagnetic energy to heat. When hyperthermia is applied, the cancerous cells get devastated due to their local increase in temperature. The Cobalt ferrite magnetic nanoparticles were considered for hyperthermia applications to destroy tumor cells locally. The magnetic nanoparticles were synthesized using co-precipitation method and were coated with polyacrylic acid as it exhibited toxic properties when it was subjected to analysis. Thus, it was characterized using SEM, XRD, VSM and FTIR. Also, the magnetic nanoparticles were tested for its cellular uptake. By suspending the magnetic nanoparticles into the aqueous environment where the brine shrimp larvae were habituated, the cellular uptake was studied with respect to time. It is implied that the cells were subjected to necrosis. This can be measured in several different ways such as assessing cell viability.