Medical laser mass spectrometric standardless microanalysis.

This paper deals with application of the laser mass spectrometry method for the standardless elementary analysis of the medical and biological samples. Reviewed is process of the laser emission interaction with the target substance and ion formation. Illustrated is the radical possibility of using laser ionization for standardless analysis. The primary criterion of such a possibility is the laser emission power density. The obtained results were used for the non-standard analysis of the medical and biological samples on the EMAL-2 device series-produced in the USSR. The mass spectra of the liver tissue and whole blood without preliminary preparation (liberation from the organic part) are presented. The issues of using this method as regards the sanitary and hygienic, toxicological and diagnostic tasks associated with the change in the microelementary composition of the tissues and biological fluids are substantiated.