{"title":"受外部刺激的丘脑下-苍白质网络模型","authors":"S. Leondopulos, E. Micheli-Tzanakou","doi":"10.1109/IJCNN.2007.4371436","DOIUrl":null,"url":null,"abstract":"A model of the subthalamo-pallidal loop using integrate-and-fire neurons in conjunction with first order models of synaptic afferents, calcium and potassium currents, and a leaky sodium current exhibits activity similar to that recorded in the Subthalamic nucleus of Parkinson patients undergoing stereotactic neurosurgery and deep brain stimulation (DBS). In particular, by incorporating a negative feedback loop, the model produces inhibitory responses to individual DBS pulses and exhibits oscillations in the alpha and beta range (8-29 Hz). Moreover, an increase in either DBS stimulus energy or GPe spontaneous activity causes the oscillatory behavior to subside.","PeriodicalId":350091,"journal":{"name":"2007 International Joint Conference on Neural Networks","volume":"11 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2007-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"A Model of the Subthalamo-Pallidal Network Undergoing Extrinsic Stimulation\",\"authors\":\"S. Leondopulos, E. Micheli-Tzanakou\",\"doi\":\"10.1109/IJCNN.2007.4371436\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A model of the subthalamo-pallidal loop using integrate-and-fire neurons in conjunction with first order models of synaptic afferents, calcium and potassium currents, and a leaky sodium current exhibits activity similar to that recorded in the Subthalamic nucleus of Parkinson patients undergoing stereotactic neurosurgery and deep brain stimulation (DBS). In particular, by incorporating a negative feedback loop, the model produces inhibitory responses to individual DBS pulses and exhibits oscillations in the alpha and beta range (8-29 Hz). Moreover, an increase in either DBS stimulus energy or GPe spontaneous activity causes the oscillatory behavior to subside.\",\"PeriodicalId\":350091,\"journal\":{\"name\":\"2007 International Joint Conference on Neural Networks\",\"volume\":\"11 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-10-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2007 International Joint Conference on Neural Networks\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/IJCNN.2007.4371436\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2007 International Joint Conference on Neural Networks","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/IJCNN.2007.4371436","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Model of the Subthalamo-Pallidal Network Undergoing Extrinsic Stimulation
A model of the subthalamo-pallidal loop using integrate-and-fire neurons in conjunction with first order models of synaptic afferents, calcium and potassium currents, and a leaky sodium current exhibits activity similar to that recorded in the Subthalamic nucleus of Parkinson patients undergoing stereotactic neurosurgery and deep brain stimulation (DBS). In particular, by incorporating a negative feedback loop, the model produces inhibitory responses to individual DBS pulses and exhibits oscillations in the alpha and beta range (8-29 Hz). Moreover, an increase in either DBS stimulus energy or GPe spontaneous activity causes the oscillatory behavior to subside.
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