H. B. Gabriel, R. A. Sussmann, E. A. Kimura, A. A. M. Rodriguez, I. B. Verdaguer, Gabriela Carolina Fernandes Leite, A. Katzin
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引用次数: 8
摘要
促使世界上疟疾病例发病率和死亡率上升的一个事实是，这种寄生虫对化疗药物具有耐药性。因此，有必要确定针对寄生虫的新的潜在靶点，以便能够进行合理的规划。评估潜在抗疟化合物的一个靶标是类异戊二烯的合成，它在恶性疟原虫中通过2- c -甲基-d-赤藓糖醇-4-磷酸途径发生。在寄生虫中发现了这一途径的几个中介和最终产物，并使我们得出结论，它与脊椎动物宿主不同。在这一章中，我们描述了一些单萜类和倍半萜类作为潜在的抗疟药物对恶性疟原虫和伯氏疟原虫的作用。
A fact which favors the increase in morbidity and mortality of malaria cases in the world is the resistance to chemotherapeutic agents that the parasite presents. Therefore, it is necessary to identify new potential targets specific to the parasite in order to be able to perform a rational planning. One target for the evaluation of potential antimalarial compounds is isoprenoid synthesis, which occurs via the 2-C-methyl-d-erythritol-4-phosphate pathway in Plasmodium falciparum. Several intermediaries and final products of this pathway were identified in the parasite and lead us to the conclusion that it is different from the vertebrate host. In this chapter, we describe the effect of some monoterpenes and sesquiterpenes on Plasmodium falciparum and Plasmodium berghei as potential antimalarial drugs.
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