评价髓过氧化物酶/对氧磷酶1比值作为多囊卵巢综合征中功能障碍HDL的决定因素

Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi Pub Date : 2023-07-06 DOI:10.38136/jgon.1313215

E. M. Erol Koç, S. Yaman, Meryem Ceyhan, S. Neşelioğlu, Ö. Erel, Melike Doğanay

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摘要

目的:髓过氧化物酶/对氧磷酶1(MPO/PON1)比值反映了氧化应激的一种指标——HDL功能障碍(d-HDL)。本研究旨在评价多囊卵巢综合征(PCOS)患者MPO/PON1比值。材料与方法:本前瞻性研究共纳入123例患者。研究组包括诊断为PCOS的妇女(n=63)与对照组包括健康妇女(n=60)进行比较。记录各组的社会人口学特征和临床特征。测定血清HDL水平、MPO和PON1活性。结果:PCOS患者MPO升高，PON1活性降低(p

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Evaluation of the myeloperoxidase/paraoxonase1 ratio as the determinant of dysfunctional HDL in polycystic ovary syndrome

Aim: The myeloperoxidase/paraoxonase1(MPO/PON1) ratio is known to reflect the dysfunctional HDL(d-HDL) which is a measure of oxidative stress. This study aimed to evaluate the MPO/PON1 ratio in polycystic ovary syndrome(PCOS). Materials and Method: This prospective study included a total of 123 patients. The study group including the women with the diagnosis of PCOS (n=63) was compared to the control group including the healthy women (n=60). Sociodemographic characteristics, and clinical features of the groups were recorded. Serum HDL level, MPO, and PON1 activities were evaluated. Results: The PCOS patients were observed to have increased MPO and decreased PON1 activities (p

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Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi

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