Slowed Development of Natural Products for Chagas Disease, how to Move Forward?

Chagas disease, caused by Trypanosoma cruzi , is considered an endemic disease that affects millions of people causing generating health, economic and social problems. This study provides a review on research and development of new therapies for Chagas based in natural products of plant origin. We observed that there are more than 400 plant spe - cies that have been evaluated against different models of Chagas disease, and in some cases, there are interesting results. Challenge that hinders research work is the puri - fication of the active compound and standardization of the chemical profile of whole extracts. The principal common factor that delays clinical testing is the lack of investment for the development of these products at the clinical phase. In the search of a natural, low cost and available drug for Chagas disease, we propose the use of new methodologies to overcome the existing challenges. The use of plant metabolomic technique is proposed as an option with high potential for the identification of biomarkers that could allow the standardization of chemical profiles. Furthermore, we describe the importance of apply ing good agricultural and manufacturing practices for reaching a successful development of quality phytotherapeutic products.