一种考虑变长基序和突变的DNA基序查找和排序改进算法

Adnan Ferdous Ashrafi, A. Newaz, Rasif Ajwad, M. Tanvee, Md. A. Mottalib
{"title":"一种考虑变长基序和突变的DNA基序查找和排序改进算法","authors":"Adnan Ferdous Ashrafi, A. Newaz, Rasif Ajwad, M. Tanvee, Md. A. Mottalib","doi":"10.1109/RETIS.2015.7232844","DOIUrl":null,"url":null,"abstract":"With the evolution of time the gene composition of species have changed a lot. Consequently it has mutated to generate new diseases and traits. In order to identify genes or coding sections of a DNA sequence it is imperative to find out the promoter regions or the conserved regions of the DNA code first. But the main problem stands that the databases for these information are quite messy and needs to be researched. The main problems in finding motifs in a DNA sequence are finding a good and fast algorithm, considering mutations in those motifs, representing variable length motifs and being species generic. In this paper we tried to formulate a new algorithm which is fast, accurate and effective. Instead of general string matching of DNA sequences we have done integer mapping and matching which are comparatively fast and accurate. Besides in order to formulate a complete DNA motif finding algorithm we also need a generalized and rational fitness function for evaluating the potential motifs. Thus we have formulated a desirable fitness function that enables us to compare the relativity among potential motifs and finally to predict a certain motif for the input DNA sequences.","PeriodicalId":161306,"journal":{"name":"2015 IEEE 2nd International Conference on Recent Trends in Information Systems (ReTIS)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2015-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"A modified algorithm for DNA motif finding and ranking considering variable length motif and mutation\",\"authors\":\"Adnan Ferdous Ashrafi, A. Newaz, Rasif Ajwad, M. Tanvee, Md. A. Mottalib\",\"doi\":\"10.1109/RETIS.2015.7232844\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"With the evolution of time the gene composition of species have changed a lot. Consequently it has mutated to generate new diseases and traits. In order to identify genes or coding sections of a DNA sequence it is imperative to find out the promoter regions or the conserved regions of the DNA code first. But the main problem stands that the databases for these information are quite messy and needs to be researched. The main problems in finding motifs in a DNA sequence are finding a good and fast algorithm, considering mutations in those motifs, representing variable length motifs and being species generic. In this paper we tried to formulate a new algorithm which is fast, accurate and effective. Instead of general string matching of DNA sequences we have done integer mapping and matching which are comparatively fast and accurate. Besides in order to formulate a complete DNA motif finding algorithm we also need a generalized and rational fitness function for evaluating the potential motifs. Thus we have formulated a desirable fitness function that enables us to compare the relativity among potential motifs and finally to predict a certain motif for the input DNA sequences.\",\"PeriodicalId\":161306,\"journal\":{\"name\":\"2015 IEEE 2nd International Conference on Recent Trends in Information Systems (ReTIS)\",\"volume\":\"17 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2015 IEEE 2nd International Conference on Recent Trends in Information Systems (ReTIS)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/RETIS.2015.7232844\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2015 IEEE 2nd International Conference on Recent Trends in Information Systems (ReTIS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/RETIS.2015.7232844","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5

摘要

随着时间的推移,物种的基因组成发生了很大的变化。因此,它发生了突变,产生了新的疾病和特征。为了鉴定基因或DNA序列的编码片段,首先必须找出DNA密码的启动子区域或保守区域。但主要的问题是,这些信息的数据库相当混乱,需要研究。在DNA序列中寻找基序的主要问题是找到一个好的、快速的算法,考虑基序的突变,表示可变长度的基序,并具有物种通用性。本文试图提出一种快速、准确、有效的新算法。代替传统的DNA序列的字符串匹配,我们进行了快速、准确的整数映射和匹配。此外,为了制定一个完整的DNA基序查找算法,还需要一个广义的、合理的适应度函数来评估潜在的基序。因此,我们制定了一个理想的适应度函数,使我们能够比较潜在基序之间的相关性,并最终预测输入DNA序列的某个基序。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A modified algorithm for DNA motif finding and ranking considering variable length motif and mutation
With the evolution of time the gene composition of species have changed a lot. Consequently it has mutated to generate new diseases and traits. In order to identify genes or coding sections of a DNA sequence it is imperative to find out the promoter regions or the conserved regions of the DNA code first. But the main problem stands that the databases for these information are quite messy and needs to be researched. The main problems in finding motifs in a DNA sequence are finding a good and fast algorithm, considering mutations in those motifs, representing variable length motifs and being species generic. In this paper we tried to formulate a new algorithm which is fast, accurate and effective. Instead of general string matching of DNA sequences we have done integer mapping and matching which are comparatively fast and accurate. Besides in order to formulate a complete DNA motif finding algorithm we also need a generalized and rational fitness function for evaluating the potential motifs. Thus we have formulated a desirable fitness function that enables us to compare the relativity among potential motifs and finally to predict a certain motif for the input DNA sequences.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信