药物重新分析/重新利用的系统综述

B. Sharma, Dinesh Yadav
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引用次数: 0

摘要

药物再利用的核心能力使越来越多的不同疾病患者能够使用已知安全性的各种药物。考虑到当前的制药市场,我们有许多药物被美国食品和药物管理局批准和重新利用。开发一种新的药物分子并将其从实验室推向市场需要大量的资金、精力和时间投资。另一方面,重新利用一种药物有能力以无害、容易获得和廉价的质量带来最好的治疗方法。西地那非、氯喹、二甲双胍是在多种疾病模型中使用的重新用途药物的一些例子。尽管面临许多挑战,药物再利用仍然是任何综合性药物再发现战略的核心组成部分,这些战略已计划为患有各种可怕疾病的患者带来好处。在这篇综述中,我们讨论了多种类型的癌症,致命的新型冠状病毒(SARS-CoV-2)和一些孤儿疾病的各种重新用途药物。本文列举了一些仍处于临床试验阶段的药物,这些药物很有可能被批准为造福人类的再用途药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A systematic review on Drug Re-profiling/Re-Purposing
Hardcore capability of drug repurposing has allowed rising population of diversified diseased patients to approach various medications with known safety profiles. In an ongoing scenario considering current pharmaceutical market, we have numerous drugs that are approved and repurposed by the U.S. Food and Drug Administration. Developing and bringing a novel drug molecule from the laboratory to a market requires a lot of investment in terms of money, efforts, and time. On the other hand, repurposing a drug holds the capability of bringing out best cures with harmless, ease availability and inexpensive quality. Sildenafil, Chloroquine, Metformin are some examples of repurposed drug used in multiple disease models. Despite numerous challenges, drug repurposing stood to be a core component to any comprehensive drug re-discovering strategies which has been planned to bring benefit to the patients suffering from a wide variety of dreadful ailments. In this review, we have discussed the various repurposed drugs in numerous types of cancer, deadly novel coronavirus (SARS-CoV-2) and some orphan diseases. This paper holds various examples of drugs which are still under clinical trial and have high chances of being approved as repurposed drugs benefitting humankind.
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