Ákos Farkas, H. Urlaub, K. Bohnsack, B. Schwappach
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Regulated targeting of the monotopic hairpin membrane protein Erg1 requires the GET pathway
Farkas et al. identify monotopic hairpin proteins as novel clients of the guided entry of tail-anchored proteins (GET) pathway. They demonstrate that high efficiency GET pathway–mediated ER targeting of the budding yeast hairpin protein Erg1, a key enzyme of sterol synthesis, becomes essential under conditions requiring increased Erg1 biogenetic flux.
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