老年外伤性脑损伤患者手术与保守治疗的结果

S. Yousefzadeh-Chabok, Z. Reihanian, Seyed Mohsen Aghapour, B. Alijani, Enayatollah Bijani, S. Jafari, Sedighe Mansoori, Mahsa Pakseresht-mogharab
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摘要

背景与目的:外伤性脑损伤(TBI)患者,尤其是老年人,手术治疗与保守治疗哪一种恢复效果最好、不良反应最少,目前尚不清楚。在老年TBI患者中使用侵入性与保守性治疗是有争议的,目前的老年脑外科手术还需要进一步的评估。方法和材料/患者:回顾性队列研究238例65岁以上TBI患者(119例手术治疗,119例保守治疗)的医疗记录。比较患者的格拉斯哥预后评分(GOS)和术后并发症的恢复程度。结果:手术入路与保守入路的原发性格拉斯哥昏迷评分(GCS)差异无统计学意义,但两种治疗方案后GCS和GOS的评估差异有统计学意义;然而,在多变量logistic回归模型中调整基线参数后,两组在CGS和恢复状态上的差异变为不显著。在治疗后的后遗症,包括挫伤、脑积水、心肌梗死、肺部感染和死亡方面,手术治疗和保守治疗没有差异。然而,在多因素回归模型后,采用保守方法治疗的血肿复发率明显较高。结论:在65岁以上的TBI患者中,手术治疗比保守治疗效果更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Outcome of Surgical Versus Conservative Management in Old Patients With Traumatic Brain Injury
Background and Aim: It is still unclear whether the surgical or conservative approach has the best recovery and the least adverse outcomes after the treatment of patients with traumatic brain injury (TBI), especially the elderly. The use of invasive versus conservative therapies in elderly patients with TBI is controversial, and the current brain surgery procedures for the elderly require further evaluation. Methods and Materials/Patients: In this retrospective cohort study, the medical records of 238 patients with TBI (119 surgical patients and 119 patients treated with conservative methods) over the age of 65 were reviewed. The patients were compared for the degree of recovery indicated by the Glasgow outcome score (GOS) and postoperative complications. Results: No difference was found in the primary Glasgow coma scale (GCS) between surgical and conservative approaches, but after two treatment protocols, the assessment of GCS and GOS showed a significant difference between the two groups; however, after adjusting baseline parameters in a multivariable logistic regression model, the difference between the two groups in CGS and recovery state turned to insignificance. There was no difference between surgical and conservative management in the post-treatment sequels, including contusion, hydrocephalus, myocardial infarction, pulmonary infection, and death. However, the recurrence of hematoma was significantly higher in those who were treated by the conservative method even after multivariate regression modeling. Conclusion: In TBI patients aged over 65 years, surgical management can result in more favorable outcomes compared with the conservative approach.
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