视场外放射性对MP4A [/sup 11/C]三维PET动态测量的影响

1998 IEEE Nuclear Science Symposium Conference Record. 1998 IEEE Nuclear Science Symposium and Medical Imaging Conference (Cat. No.98CH36255) Pub Date : 1998-11-08 DOI:10.1109/NSSMIC.1998.773887

T. Hasegawa, M. Suzuki, H. Murayama, T. Irie, K. Fukushi, Y. Wada

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引用次数: 6

摘要

本研究评估了视场外放射性对示踪剂[/sup 11/C] n -甲基-4-胡椒酰乙酸酯用正电子发射断层扫描三维模式测量脑乙酰胆碱酯酶(AChE)活性的影响。从一名志愿者的动态扫描中发现，在注射示踪剂后，胸部视距外的放射性远远高于大脑。利用所实现的散射和衰减校正和重建算法，进行了具有代表性的幻像测量，以量化视场外辐射引起的系统误差。在所有感兴趣的大脑区域中，由室室模型分析计算出的乙酰胆碱酯酶活性(k3参数)的误差小于1%。

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Influence of radioactivity out of the field of view on 3D PET dynamic measurement with [/sup 11/C]MP4A

This study assessed the influence of radioactivity out of the field of view (out-of-FOV) on the measurement of brain acetylcholinesterase (AChE) activity with tracer [/sup 11/C] N-methyl-4-piperidyl-acetate by positron emission tomography in the three-dimensional mode. From dynamic scans on a volunteer, it was found that the out-of-FOV radioactivity in the chest was much higher than that of the brain immediately after tracer injection. Representative phantom measurement was performed to quantitate systematic errors due to the out-of-FOV radioactivity using the implemented scatter and attenuation correction and reconstruction algorithms. Resultant errors in the AChE activity (k3 parameter) as calculated by compartment model analysis were found to be less than about one percent in all of the brain regions of interest.

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来源期刊

1998 IEEE Nuclear Science Symposium Conference Record. 1998 IEEE Nuclear Science Symposium and Medical Imaging Conference (Cat. No.98CH36255)

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