胃窦内注射肉毒杆菌与饮食:比较研究

B. Kasapoglu, A. Yozgat, M. Keki̇lli̇
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引用次数: 1

摘要

在这项研究中,我们的目的是报告在没有广泛注射的情况下静脉注射BTX-A的临床结果,并将结果与只接受饮食计划而没有任何侵入性手术的对照病例进行比较。方法:对42例患者进行BTX-A灌胃注射。与此同时,38名年龄和性别匹配的患者开始了一项新的饮食计划,并被纳入对照组。仅纳入体重指数(BMI)在30 kg/m2至35 kg/m2之间的患者进行分析。结果:本研究共纳入42例(男11例,女31例)胃内注射BTX-A患者和38例(男8例,女30例)节食患者。BTX-A组5个月期间最小体重减轻7 kg,最大体重减轻19 kg,平均14.48±2.20 kg;对照组5个月的最小减重5 kg,最大减重13 kg,平均减重10.78±2.09 kg (p=0.001)。讨论与结论:在1级肥胖患者中,胃内注射BTX-A,几乎不注射到胃窦,比单纯饮食和运动更有效地诱导体重减轻。经静脉注射BTX-A后约3个月体重减轻约10%-15%,无明显不良事件发生。在这方面,胃内注射BTX-A可能是肥胖患者诱导减肥的一种很有前途的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intragastric Botox Injection Barely To the Antrum vs. Diet: A Comparative Study
Introduction: In this study, we aimed to report the clinical outcomes of antral BTX-A injection in the absence of wide- spread injections and compare the results with the control cases who only were under a diet program without any invasive procedure. Methods: Intragastric BTX-A injection was performed in 42 patients. Meanwhile, 38 age- and gender-matched pa- tients who started a new diet program were included in the control group. Only the patients with a body mass index (BMI) between 30 kg/m2 and 35 kg/m2 were included for analysis. Results: In total, 42 patients (11 males, 31 females) who had intragastric BTX-A injection and 38 patients (8 males, 30 females) who were under a diet program were included in this study. In the group administered with BTX-A, the mini- mum weight loss in this 5-month period was 7 kg, and the maximum weight lost was 19 kg with a mean of 14.48±2.20 kg; while the minimum weight loss in this 5-month period was 5 kg and the maximum weight lost was 13 kg with a mean of 10.78±2.09 kg in the control group (p=0.001). Discussion and Conclusion: Intragastric BTX-A injection, barely to the antrum, was determined to be more effec- tive in inducing significant weight loss in patients with grade 1 obesity than only diet and exercise. Approximately 10%–15% weight loss was achieved after antral BTX-A injection in about 3 months without any significant adverse events. In that aspect, intragastric BTX-A injection could be a promising way of inducing weight loss in obese patients.
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