2019冠状病毒病与精神障碍:发展机制和发现可能性综述

О. С. Шевченко, Л. Д. Тодоріко, Вячеслав Юрійович Петренко, В.П. Киба, О.О. Погорєлова
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摘要

目的:通过文献分析,发现新冠肺炎相关的主要精神障碍及其发病机制。材料和方法。我们分析了PubMed数据库中112篇关于“Covid与心理健康”、“Covid与精神障碍”的文献来源,并从中选择36篇进行详细研究。结果和讨论。研究发现,COVID-19患者通常患有多种神经和精神障碍,如躁动(69%)、皮质脊髓束损伤迹象(67%)、精神混乱(65%)和神经心理障碍(33%)。在冠状病毒感染后观察到的精神障碍中,最常见的是失眠(42%)、注意力集中下降(38%)、焦虑(36%)、记忆障碍(34%)、抑郁(33%)、意识混乱(28%)和其他意识障碍(21%)。人口中最脆弱的群体是儿童、青少年和老年人,他们不仅遭受疾病本身的痛苦,而且还遭受孤立的后果。应特别注意保健专业人员,他们通常患有焦虑(12 - 20%)、抑郁(15 - 25%)、失眠(8%)和创伤后应激障碍(35 - 49%)。结论。COVID-19大流行已经对人口的心理健康产生了深刻而强烈的影响。这一点在精神疾病患者、医务工作者、老年人和经济困难的人等人口群体中尤为突出。鉴于可能出现新一波COVID-19疾病和加强隔离限制,以及未来可能出现新的流行病,必须制定明确的指导方针,以帮助减轻大流行危机和限制性措施的影响,并防止大规模的精神健康恶化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID­19 and mental disorders: mechanisms of development and possibility of detection: a review
Objective — to find the mainCOVID-19-associated psychiatric disorders and mechanisms of their development basing on the literature analysis. Materials and methods. 112 literature sources from the PubMed database for the queries «Covid AND mental health», «Covid AND mental disorders» were analyzed and 36 of them were selected for detailed study. Results and discussion. It were found that patients with COVID-19 often have multiple neurological and mental disorders, such as agitation (69 %), signs of damage to the corticospinal tract (67 %), confusion (65 %) and neuropsychological disorders (33 %). Among the mental disorders that are observed after a coronavirus disease, the most common are insomnia (42 %), decreased concentration and attention (38 %), anxiety (36 %), memory disorders (34 %), depression (33 %), confusion (28 %) and other disorders of consciousness (21 %). The most vulnerable contingents of the population are children, adolescents and the elderly, who suffer not only from the disease itself, but also from the consequences of isolation. Special attention should be paid to healthcare professionals, who often have anxiety (12—20 %), depression (15—25 %), insomnia (8 %) and post-traumatic stress disorder (35—49 %). Conclusions. The COVID-19 pandemic has already profoundly strongly influenced the mental health of the population. This was especially reflected in such groups of the population as patients with psychiatric pathology, medical workers, the elderly and people in difficult financial situations. Given the potential for new waves of COVID-19 disease and increased quarantine restrictions, as well as the possibility of new epidemics in the future, it is important to make clear guidelines that will help mitigate the impact of the pandemic crisis and restrictive measures and prevent massive mental health deterioration.
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