COVID-19疫苗与血栓形成的关系——文献综述

Gustavo Pereira Persch, G. Fernandes, Caio Álvares Bitencourt, F. Ferreira, F. Xavier
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引用次数: 0

摘要

在过去的几个月里,已经报道了几例与COVID-19疫苗相关的血栓栓塞事件。这些事件导致临床医生和机构禁止在一个亚组患者中使用ChAdOx1疫苗。然而,其中一些建议没有得到科学证明,延迟接种疫苗可能比这些疫苗的理论风险输入更危险。此外,与疫苗相关的血栓形成机制与通常在非血液科门诊环境中看到的机制有很大不同。此外,这些血栓形成的临床表现类似于肝素诱导的血小板减少症,由于一些患者的临床和实验室有相似之处,这种情况被命名为疫苗诱导的血栓性血小板减少症。本综述旨在向医学界,特别是非血液科医师,解释如何诊断、管理和治疗这种疾病
本文章由计算机程序翻译,如有差异,请以英文原文为准。
THE RELATIONSHIP BETWEEN THROMBOSIS AND COVID-19 VACCINES - LITERATURE REVIEW
Over the last couple of months, a few cases of thromboembolic events related to COVID-19 vaccines have been described. Those events cause clinicians and institutions to contraindicate the ChAdOx1 vaccine in a subgroup of patients. However, some of these recommendations are not scientifically proven, and delayed vaccination can be more dangerous than the theoretical risk input to these vaccines. Also, the mechanism of thrombosis related to vaccines is quite different from the mechanism usually seen in the outpatient setting of non-hematologists. Additionally, those thrombosis’s clinical picture resembles the Heparin-Induced Thrombocytopenia, and because some patients have clinical and laboratory similarities, this condition was named Vaccine-Induced Thrombotic Thrombocytopenia. This review aims to explain to the medical community, especially those non-hematologists, how to diagnose, manage, and treat this
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