Kaʻahukane Leite-Ah Yo, Kekaihalai Avilez, T. Hemscheidt, Dana-lynn Koʻoma Lange, A. Maunakea
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引用次数: 0
摘要
夏威夷土著传统的健康概念固有的认识是,包括营养和社会行为在内的环境因素会跨代影响个人和社区的健康结果。表观遗传机制现在可以解释这些环境因素和健康结果之间的分子联系。本文探讨了夏威夷祖先健康智慧中的表观遗传学概念,并举例说明这些知识启发了诺丽(Morinda citrifolia)抗癌活性的进一步生物学见解。诺丽是许多药用植物中的一种,几个世纪以来一直被夏威夷土著健康从业者使用,kāhuna lā ' au lapa ' au,用于治疗各种健康疾病,包括癌症。在这里,我们报告了诺丽的抗癌作用与表观遗传基因调控之间的联系,这表明传统的夏威夷土著健康概念可能包含了环境对身体健康和健康的作用的机制原理。
E Hō mai ka ‘Ike Kupuna no ke Ola: Links between Traditional Native Hawaiian Concepts of Health and Epigenetic Research
Inherent in the traditional Native Hawaiian concept of health is the understanding that environmental factors, including nutrition and social behaviors, trans-generationally impact health outcomes in individuals and communities. Epigenetic mechanisms may now explain molecular links between these environmental factors and health outcomes. This article explores the epigenetic concepts present in ancestral Hawaiian wisdom of health as well as an example that this knowledge inspired further biological insight into the anticancer activities of noni (Morinda citrifolia). Noni is one of many medicinal plants that have been utilized for centuries by Native Hawaiian health practitioners, kāhuna lā‘au lapa‘au, to address various health ailments, including cancer. Here, we report a link between the anti-cancer effects of noni and epigenetic gene regulation, suggesting that the traditional Native Hawaiian concept of health likely included a mechanistic rationale for the role of the environment on physical health and wellness.