菜豆科菜豆对小鼠的降血脂作用

R. MEX-ÁLVAREZ, María Magali Guillen-Morales, Patricia Margarita Garma-Quen, Lázaro Guadalupe RAMOS-GOMEZ
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引用次数: 0

摘要

目的:用Triton X-100建立高脂血症诱导模型,评价菜豆种子水提物对雄性小鼠的降脂作用。方法:采用测定总多酚(Folin Ciocalteu法)和总花青素(比色法)的方法对提取液的化学性质进行表征,并采用铁离子还原能力(FRAP法、TPTZ法)测定其抗氧化活性。结果:水提物中含有大量的总多酚(415 mg EAG / 100g种子)和总花青素(43EMG / 100g种子),具有显著的抗氧化活性(11.080.83 Fex / g种子)。对高脂血症小鼠给予水提取物改善了它们的脂质谱,特别是通过降低血清总胆固醇(144毫克/分升)和甘油三酯(147毫克/分升)和增加高密度脂蛋白值(67毫克/分升),接受300毫克/公斤体重提取物的组。结论:本实验结果表明,黄芪水提物具有体外抗氧化活性和小鼠降脂作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypolipidemic activity of Phaseolus vulgaris (Fabaceae) in mice
Objective: To evaluate the lipid-lowering activity of an aqueous extract obtained from the seeds of Phaseolus vulgaris in male mice using the hyperlipidemia induction model with Triton X-100. Methods: the chemical quality of the extract obtained was characterized by quantifying the total polyphenols (Folin Ciocalteu method) and total anthocyanins (colorimetric method) as well as their antioxidant activity by their ferric ion reducing capacity (FRAP, TPTZ method). Results: The data obtained show that the aqueous extract contains a large amount of total polyphenols (415 mg EAG / 100g of seed) and total anthocyanins (43EMG / 100 g of seed) and significant antioxidant activity (11.080.83 of Fex / g of seed). Administration of the aqueous extract to hyperlipidemic mice improved their lipid profile, especially by reducing the serum value of total cholesterol (144 mg/dL) and triglycerides (147 mg/dL) and increasing HDL values (67 mg/dL) in the group that received a dose of 300 mg of extract / kg of weight. Conclusion: These results show that the aqueous extract of P. vulgaris exerts an antioxidant activity in vitro and a lipid-lowering effect in mice.
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