胶原降解产物(CDP)对中枢神经系统的影响。

Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis Pub Date : 1992-01-01

E Telejko, J Maćkowiak, J Ksiazek, K Wiśniewski

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引用次数: 0

摘要

用细菌胶原酶消化大鼠ⅰ型胶原。获得的多肽在Sephadex G-25上进行凝胶过滤。得到了两个分子量不同的组分(CDP I-3000 D和CDP II-1200 D)。在Lat’s试验中发现，给大鼠服用的这些组分对中枢神经系统(CNS)有抑制作用，并且在运动计上记录的动物的活动能力被发现降低。这种作用依赖于肽的剂量，并且在静脉注射(iv)和脑室注射(icv)后发生。

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The effect of collagen degradation products (CDP) on the central nervous system (CNS).

Rat collagen type I was digested with bacterial collagenase. The peptides obtained were submitted to gel filtration on Sephadex G-25. Two fractions differing in molecular weight (CDP I-3000 D and CDP II-1200 D) were obtained. These fractions administered to rats were found to have an inhibiting effect on the central nervous system (CNS) in Lat's test and the mobility of the animals recorded on a motimeter was found to be reduced. This effect was dependent on the peptide dose and occurred after intravenous (iv) as well as intraventricular (icv) injection.

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Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis

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