{"title":"mirna在胆管疾病发展中的作用。第1部分","authors":"A. Abaturov, V. Babуch","doi":"10.22141/2224-0551.18.4.2023.1606","DOIUrl":null,"url":null,"abstract":"The role of miRNA in the development of cholangiopathies is given in the scientific review. This article discusses the role of miRNA in primary sclerosing cholangitis and primary biliary cholangitis. To write the article, information was searched using Scopus, Web of Science, MedLine, PubMed, Google Scholar, Embase, Global Health, The Cochrane Library databases. The authors state that in hepatobiliary diseases, namely cholangiopathies, micro-RNAs affect the regulation of hepatocyte, cholangiocyte proliferation, cell cycle, inflammatory processes, fibrosis, chemoresistance and cell survival. Researchers have determined that patients with primary sclerosing cholangitis have significantly increased levels of miR-26a, miR-30b, miR-126, miR-122, miR-194, miR-1281 in blood serum and miR-412, miR-640, miR-1537 and miR-3189 in the bile of relatively healthy individuals. It is known that the number of differentially expressed miRNAs in patients with primary biliary cholangitis reaches 97, of which the most diagnostically significant is miR-139-5p. Scientists note that increased miR-139-5p expression in hepatocytes correlates with increased production of TNF-α and repression of c-FOS gene transcription. It is stated that the researchers proposed an alternative hypothesis of miRNA-mediated induction of the inflammatory reaction of the bile ducts in primary biliary cholangitis. The hypothesis is presented that the activity of the generation of miR-106b-5p, miR-20a-5p, and miR-93-5p, which perform key regulatory functions in it, is the basis of the functioning of the miRNA-mRNA network in primary biliary cholangitis. Thus, the data of modern research indicate that cholangiopathies are accompanied by a change in the spectrum of production of various micro-RNAs that regulate the activation of inflammation, regeneration, proliferation, apoptosis of hepatocytes and cholangiocytes. A decrease or increase in the level of some micro-RNA expression is critical in the pathological processes that occur in primary sclerosing cholangitis and primary biliary cholangitis, but micro-RNAs can be not only markers, but also targets of these processes.","PeriodicalId":338009,"journal":{"name":"CHILD`S HEALTH","volume":"79 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of miRNAs in the development of cholangiopathies. Part 1\",\"authors\":\"A. Abaturov, V. Babуch\",\"doi\":\"10.22141/2224-0551.18.4.2023.1606\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The role of miRNA in the development of cholangiopathies is given in the scientific review. This article discusses the role of miRNA in primary sclerosing cholangitis and primary biliary cholangitis. 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Scientists note that increased miR-139-5p expression in hepatocytes correlates with increased production of TNF-α and repression of c-FOS gene transcription. It is stated that the researchers proposed an alternative hypothesis of miRNA-mediated induction of the inflammatory reaction of the bile ducts in primary biliary cholangitis. The hypothesis is presented that the activity of the generation of miR-106b-5p, miR-20a-5p, and miR-93-5p, which perform key regulatory functions in it, is the basis of the functioning of the miRNA-mRNA network in primary biliary cholangitis. Thus, the data of modern research indicate that cholangiopathies are accompanied by a change in the spectrum of production of various micro-RNAs that regulate the activation of inflammation, regeneration, proliferation, apoptosis of hepatocytes and cholangiocytes. 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引用次数: 0
摘要
在科学综述中给出了miRNA在胆管病变发生发展中的作用。本文讨论了miRNA在原发性硬化性胆管炎和原发性胆道胆管炎中的作用。为了撰写这篇文章,我们使用Scopus、Web of Science、MedLine、PubMed、Google Scholar、Embase、Global Health、Cochrane Library等数据库进行了信息搜索。作者指出,在肝胆疾病,即胆管病变中,微rna影响肝细胞、胆管细胞增殖、细胞周期、炎症过程、纤维化、化疗耐药和细胞存活的调节。研究人员已经确定,原发性硬化性胆管炎患者血清中的miR-26a、miR-30b、miR-126、miR-122、miR-194、miR-1281水平以及相对健康个体胆汁中的miR-412、miR-640、miR-1537和miR-3189水平显著升高。已知原发性胆道胆管炎患者中差异表达的mirna数量达到97个,其中诊断意义最大的是miR-139-5p。科学家们注意到,肝细胞中miR-139-5p表达的增加与TNF-α产生的增加和c-FOS基因转录的抑制相关。据报道,研究人员提出了mirna介导的原发性胆管炎中胆管炎症反应的另一种假说。假设miR-106b-5p、miR-20a-5p和miR-93-5p的生成具有关键的调节功能,其活性是原发性胆管炎中miRNA-mRNA网络功能的基础。因此,现代研究数据表明,胆管病变伴随着各种调控肝细胞和胆管细胞炎症激活、再生、增殖、凋亡的微rna产生谱的变化。在原发性硬化性胆管炎和原发性胆管炎的病理过程中,一些微rna表达水平的降低或升高是至关重要的,但微rna不仅可以是这些过程的标志物,也可以是这些过程的靶点。
The role of miRNAs in the development of cholangiopathies. Part 1
The role of miRNA in the development of cholangiopathies is given in the scientific review. This article discusses the role of miRNA in primary sclerosing cholangitis and primary biliary cholangitis. To write the article, information was searched using Scopus, Web of Science, MedLine, PubMed, Google Scholar, Embase, Global Health, The Cochrane Library databases. The authors state that in hepatobiliary diseases, namely cholangiopathies, micro-RNAs affect the regulation of hepatocyte, cholangiocyte proliferation, cell cycle, inflammatory processes, fibrosis, chemoresistance and cell survival. Researchers have determined that patients with primary sclerosing cholangitis have significantly increased levels of miR-26a, miR-30b, miR-126, miR-122, miR-194, miR-1281 in blood serum and miR-412, miR-640, miR-1537 and miR-3189 in the bile of relatively healthy individuals. It is known that the number of differentially expressed miRNAs in patients with primary biliary cholangitis reaches 97, of which the most diagnostically significant is miR-139-5p. Scientists note that increased miR-139-5p expression in hepatocytes correlates with increased production of TNF-α and repression of c-FOS gene transcription. It is stated that the researchers proposed an alternative hypothesis of miRNA-mediated induction of the inflammatory reaction of the bile ducts in primary biliary cholangitis. The hypothesis is presented that the activity of the generation of miR-106b-5p, miR-20a-5p, and miR-93-5p, which perform key regulatory functions in it, is the basis of the functioning of the miRNA-mRNA network in primary biliary cholangitis. Thus, the data of modern research indicate that cholangiopathies are accompanied by a change in the spectrum of production of various micro-RNAs that regulate the activation of inflammation, regeneration, proliferation, apoptosis of hepatocytes and cholangiocytes. A decrease or increase in the level of some micro-RNA expression is critical in the pathological processes that occur in primary sclerosing cholangitis and primary biliary cholangitis, but micro-RNAs can be not only markers, but also targets of these processes.