Jiunn-Guang Lo , Ai-Yih Wang , Yuan-Yaw Wei , Wing-Yiu Lui , Chin-Wen Chi , Wing-Kai Chan
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Preparation of [131I]lipiodol as a hepatoma therapeutic agent
An isotopic exchange method was used to label lipiodol with 131I. The labelling efficiency was > 92.5%, and the radiochemical purity of [131I]lipiodol was above 98% as determined by ITLC. The influencing factors e.g. the heating temperature, reaction time, pH and storage conditions were studied and the optimum conditions were determined.
In a pilot study injecting [131I]lipiodol for the treatment of hepatoma, about 70% of hepatoma patients had a response to the treatment with a reduction of α-fetoprotein and decrease of hepatoma sizes. The overall median survival was 9 months (range 2–17 months).
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