CD28共刺激t细胞介导的细胞毒性。

International journal of cancer. Supplement = Journal international du cancer. Supplement Pub Date : 1992-01-01

M Azuma, J H Phillips, L L Lanier

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引用次数: 0

摘要

通过CD28途径的共刺激允许静息的人外周血T淋巴细胞介导抗cd3单克隆抗体(MAb)。“定向”细胞毒性。效应细胞包含在T淋巴细胞的“记忆”群体中，通过表达CD45RO分化抗原来识别。在本文中，我们回顾了启动细胞溶解反应的要求，并推测了这一过程的生理后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CD28 co-stimulation of T-cell-mediated cytotoxicity.

Co-stimulation via the CD28 pathway permits small, resting human peripheral-blood T lymphocytes to mediate anti-CD3 monoclonal antibody (MAb) "re-directed" cytotoxicity. The effector cells are contained with the "memory" population of T lymphocytes, identified by expression of the CD45RO differentiation antigen. In this article, we review the requirements for initiating a cytolytic response and speculate on the physiological consequences of this process.

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International journal of cancer. Supplement = Journal international du cancer. Supplement

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