制作微阵列跨平台相关性的注意事项

2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05) Pub Date : 2005-08-08 DOI:10.1109/CSBW.2005.44

M. Kollegal, S. Adak, R. Shippy, T. Sendera

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引用次数: 2

摘要

比较和整合来自不同微阵列平台的表达数据是具有挑战性的。影响微阵列数据跨平台比较的因素包括所使用的归一化方法的选择、注释差异、剪接变体的存在、RNA降解和探针到3'端的距离。本文描述了对两个商业微阵列平台的全面评估，以确定跨平台相关性的适当方法。

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Considerations in making microarray cross-platform correlations

Comparison and integration of expression data derived from diverse microarray platforms is challenging. Factors affecting cross-platform comparison of microarray data include the choice of normalization method used, annotation differences, presence of splice variants, RNA degradation and probe distance from 3' end. A thorough evaluation of two commercial microarray platforms to determine an appropriate methodology for making cross-platform correlations is described here.

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2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05)

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