Effect of Gynerium sagittatum methanol extract on testosterone-induced benign prostatic hyperplasia in rats compared with finasteride.

Article Information Gynerium sagittatum (Caña Brava) is used in ethnomedicine to treat benign prostatic hyperplasia without any scientific information on its safety profile after its administration. Evaluate the possible curative effect of methanolic extract of Gynerium sagittatum (GS) on testosterone-induced benign prostatic hyperplasia in rats. 36 male rats with an average weight of 300 g ± 50 g and 2.5 months of age were used, 6 random groups of 6 rats each were formed; Group I, blank: with physiological serum 2 mL / Kg every 24 h. for Per Orally (PO), control group II: with olive oil subcutaneous 0.5 mL + testosterone 25 mg (TA), group III: with olive oil subcutaneous 0.5 ml + testosterone 25 mg + extract of Gynerium sagittatum 50 mg/kg PO, group IV: olive oil subcutaneous 0.5 mL + testosterone 25 mg + extract of Gynerium sagittatum 250 mg/kg, Group V: olive oil subcutaneous 0.5 mL + testosterone 25 mg + extract of Gynerium sagittatum 500 mg/kg, Group VI: olive oil subcutaneous 0.5 mL + testosterone 25 mg + Finasteride 0.6 mg/kg. weighed subsequent treatments, and prostate, kidneys, and liver were measured, and a pathological study determined prostate-specific antigen and serum determination of toxicity markers by liver profile. A 99% decrease in the comparative prostate index was observed in control group I, and a better effect was observed at a dose of 500 mg/kg (P <0.004). This study has shown that GS has a beneficial effect on induced benign prostatic hyperplasia in rats.