胰岛素依赖型糖尿病患者尿胆碱酯酶活性升高:糖尿病小管功能障碍的进一步证据。

Enzyme Pub Date : 1992-01-01 DOI:10.1159/000468810
E Matteucci, L Pellegrini, C Uncini-Manganelli, M Cecere, M Saviozzi, O Giampietro
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引用次数: 3

摘要

我们测量了63名胰岛素依赖型糖尿病患者和27名对照者晨尿中的胆碱酯酶活性。总酯酶(TotE)活性(Ellman’s法)通过叶丝氨酸和奎尼丁两种抑制剂将其分为乙酰胆碱酯酶(AliE)、假胆碱酯酶和乙酰胆碱酯酶。根据尿白蛋白/肌酐比值(mg/mmol, 1组< 2,2组> 2)将糖尿病患者分为2组,尿胆碱酯酶行为与已知的小管溶酶体水解酶n -乙酰- β - d -氨基葡萄糖苷酶(NAG)相关。与正常人相比,糖尿病患者除了尿NAG显著升高(2组高于1组)外,TotE和AliE也显著升高(分别为对照组的36%和109%,1组与2组相同)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Urinary cholinesterase activity is increased in insulin-dependent diabetics: further evidence of diabetic tubular dysfunction.

We measured the cholinesterase activity in morning urines from 63 insulin-dependent diabetics and 27 controls. The total esterase (TotE) activity (Ellman's method) has been divided into aliesterase (AliE), pseudocholinesterase and acetylcholinesterase by means of two inhibitors, eserine and quinidine. Diabetics were divided in 2 groups according to the urinary albumin/creatinine ratio (mg/mmol, < 2 in group 1, > 2 in group 2). The urinary cholinesterase behavior was correlated with that of a known tubular lysosomal hydrolase, N-acetyl-beta-D-glucosaminidase (NAG). Compared to normals, in addition to a significant increase in urinary NAG in diabetes (in group 2 more than in group 1), TotE and AliE were also significantly raised (+36% and 109% of the controls, in group 1 as much as in group 2).

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